Document Detail


Unifying thoracic biomarkers: surfactant protein-D and beyond.
MedLine Citation:
PMID:  22455487     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Chronic obstructive pulmonary disease (COPD) is a progressive disorder that affects 300 million people worldwide and is responsible for 3 million deaths annually. Currently, there are no accepted biomarkers of COPD, which has impaired drug development and management of patients with COPD. Pneumoproteins, which are proteins synthesized predominantly in the lungs, are promising blood biomarkers because they have high specificity for lung disease. The most promising is surfactant protein-D, which is synthesized largely in Type 2 pneumocytes, and its blood concentrations have been associated with COPD and with certain clinical end points such as mortality. In this paper, we discuss surfactant protein-D and other pneumoproteins as promising biomarkers of COPD.
Authors:
Jen Erh Jaw; Don D Sin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of respiratory medicine     Volume:  6     ISSN:  1747-6356     ISO Abbreviation:  Expert Rev Respir Med     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278196     Medline TA:  Expert Rev Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  147-54     Citation Subset:  IM    
Affiliation:
UBC James Hogg Research Center, The Institute for Heart and Lung Health, St Paul's Hospital and Department of Medicine (Pulmonary Division), University of British Columbia, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.
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