Document Detail


Uniform transmural strain in pre-stressed arteries occurs at physiological pressure.
MedLine Citation:
PMID:  22763133     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Residual deformation (strain) exists in arterial vessels, and has been previously proposed to induce homogeneous transmural strain distribution. In this work, we present analytical formulations that predict the existence of a finite internal (homeostatic) pressure for which the transmural deformation is homogenous, and the corresponding stress field. We provide evidence on the physical existence of homeostatic pressure when the artery is modeled as an incompressible tube with orthotropic constitutive strain-energy function. Based on experimental data of rabbit carotid arteries and porcine coronary arteries, the model predicts a homeostatic mean pressure of ~90 mmHg and 70-120 mmHg, respectively. The predictions are well within the physiological pressure range. Some consequences of this strain homogeneity in the physiological pressure range are explored under the proposed assumptions.
Authors:
Michel Destrade; Yi Liu; Jeremiah G Murphy; Ghassan S Kassab
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Publication Detail:
Type:  Journal Article     Date:  2012-03-20
Journal Detail:
Title:  Journal of theoretical biology     Volume:  303     ISSN:  1095-8541     ISO Abbreviation:  J. Theor. Biol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-07-05     Completed Date:  2012-08-09     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0376342     Medline TA:  J Theor Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  93-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anisotropy
Arteries / physiology*
Blood Pressure / physiology
Carotid Arteries / physiology
Coronary Vessels / physiology
Homeostasis / physiology
Models, Cardiovascular*
Rabbits
Stress, Mechanical
Grant Support
ID/Acronym/Agency:
R01 HL087235/HL/NHLBI NIH HHS; R01 HL087235-02/HL/NHLBI NIH HHS
Comments/Corrections

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