| Uniform transmural strain in pre-stressed arteries occurs at physiological pressure. | |
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MedLine Citation:
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PMID: 22763133 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Residual deformation (strain) exists in arterial vessels, and has been previously proposed to induce homogeneous transmural strain distribution. In this work, we present analytical formulations that predict the existence of a finite internal (homeostatic) pressure for which the transmural deformation is homogenous, and the corresponding stress field. We provide evidence on the physical existence of homeostatic pressure when the artery is modeled as an incompressible tube with orthotropic constitutive strain-energy function. Based on experimental data of rabbit carotid arteries and porcine coronary arteries, the model predicts a homeostatic mean pressure of ~90 mmHg and 70-120 mmHg, respectively. The predictions are well within the physiological pressure range. Some consequences of this strain homogeneity in the physiological pressure range are explored under the proposed assumptions. |
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Authors:
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Michel Destrade; Yi Liu; Jeremiah G Murphy; Ghassan S Kassab |
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Publication Detail:
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Type: Journal Article Date: 2012-03-20 |
Journal Detail:
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Title: Journal of theoretical biology Volume: 303 ISSN: 1095-8541 ISO Abbreviation: J. Theor. Biol. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-07-05 Completed Date: 2012-08-09 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0376342 Medline TA: J Theor Biol Country: England |
Other Details:
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Languages: eng Pagination: 93-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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School of Electrical, Electronic and Mechanical Engineering, University College Dublin, Belfield, Dublin 4, Ireland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anisotropy Arteries / physiology* Blood Pressure / physiology Carotid Arteries / physiology Coronary Vessels / physiology Homeostasis / physiology Models, Cardiovascular* Rabbits Stress, Mechanical |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL087235-02/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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