| A Uniform Sub-50 nm-Sized Magnetic/Upconversion Fluorescent Bimodal Imaging Agent Capable of Generating Singlet Oxygen by Using a 980 nm Laser. | |
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MedLine Citation:
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PMID: 22544381 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Upconverting nanoparticles (UCNPs) with fascinating properties hold great potential as nanotransducers for solving the problems that traditional photodynamic therapy (PDT) has been facing. In this report, by using well-selected bifunctional gadolinium (Gd)-ion-doped UCNPs and water-soluble methylene blue (MB) combined with the water-in-oil reverse microemulsion technique, we have succeeded in developing a new kind of UCNP/MB-based PDT drug, NaYF(4) :Er/Yb/Gd@SiO(2) (MB), with a particle diameter less than 50 nm. Great efforts have been made to investigate the drug-formation mechanism and provide detailed physical and photochemical characterizations and the potential structure optimization of the as-designed PDT drug. We envision that such a PDT drug will become a potential theranostic nanomedicine for future near-infrared laser-triggered photodynamic therapy and simultaneous magnetic/optical bimodal imaging. |
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Authors:
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Feng Chen; Shengjian Zhang; Wenbo Bu; Yu Chen; Qingfeng Xiao; Jianan Liu; Huaiyong Xing; Liangping Zhou; Weijun Peng; Jianlin Shi |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-27 |
Journal Detail:
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Title: Chemistry (Weinheim an der Bergstrasse, Germany) Volume: - ISSN: 1521-3765 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9513783 Medline TA: Chemistry Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Group of Mesoporous and Low-Dimensional Nano-Materials, State Key Laboratory of High-Performance, Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, Dingxi Road 1295 Shanghai (P.R. China), Fax: (+86) 5241-3122; F. Chen and S. J. Zhang contributed equally to this work. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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