Document Detail


Unified neurophysical model of EEG spectra and evoked potentials.
MedLine Citation:
PMID:  12111274     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Evoked potentials -- the brain's transient electrical responses to discrete stimuli -- are modeled as impulse responses using a continuum model of brain electrical activity. Previous models of ongoing brain activity are refined by adding an improved model of thalamic connectivity and modulation, and by allowing for two populations of excitatory cortical neurons distinguished by their axonal ranges. Evoked potentials are shown to be modelable as an impulse response that is a sum of component responses. The component occurring about 100 ms poststimulus is attributed to sensory activation, and this, together with positive and negative feedback pathways between the cortex and thalamus, results in subsequent peaks and troughs that semiquantitatively reproduce those of observed evoked potentials. Modulation of the strengths of positive and negative feedback, in ways consistent with psychological theories of attentional focus, results in distinct responses resembling those seen in experiments involving attentional changes. The modeled impulse responses reproduce key features of typical experimental evoked response potentials: timing, relative amplitude, and number of peaks. The same model, with further modulation of feedback, also reproduces experimental spectra. Together, these results mean that a broad range of ongoing and transient electrocortical activity can be understood within a common framework, which is parameterized by values that are directly related to physiological and anatomical quantities.
Authors:
C J Rennie; P A Robinson; J J Wright
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological cybernetics     Volume:  86     ISSN:  0340-1200     ISO Abbreviation:  Biol Cybern     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-07-11     Completed Date:  2003-01-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7502533     Medline TA:  Biol Cybern     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  457-71     Citation Subset:  IM    
Affiliation:
School of Physics, University of Sydney and Department of Medical Physics, Westmead Hospital, New South Wales, Australia. rennie@physics.usyd.edu.au
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MeSH Terms
Descriptor/Qualifier:
Cerebral Cortex / cytology,  physiology
Electroencephalography*
Evoked Potentials / physiology
Humans
Models, Neurological*
Neural Pathways / physiology
Thalamus / cytology,  physiology

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