| Unidirectional rotations produce asymmetric changes in horizontal VOR gain before and after unilateral labyrinthectomy in macaques. | |
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MedLine Citation:
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PMID: 21431432 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Unilateral vestibular lesions cause marked asymmetry in the horizontal vestibulo-ocular reflex (VOR) during rapid head rotations, with VOR gain being lower for head rotations toward the lesion than for rotations in the opposite direction. Reducing this gain asymmetry by enhancing ipsilesional responses would be an important step toward improving gaze stability following vestibular lesions. To that end, there were two goals in this study. First, we wanted to determine whether we could selectively increase VOR gain in only one rotational direction in normal monkeys by exposing them to a training session comprised of a 3-h series of rotations in only one direction (1,000°/s² acceleration to a plateau of 150°/s for 1 s) while they wore 1.7 × magnifying spectacles. Second, in monkeys with unilateral vestibular lesions, we designed a paradigm intended to reduce the gain asymmetry by rotating the monkeys toward the side of the lesion in the same way as above but without spectacles. There were three main findings (1) unidirectional rotations with magnifying spectacles result in gain asymmetry in normal monkeys, (2) gain asymmetry is reduced when animals are rotated towards the side of the labyrinthectomy via the ipsilesional rotation paradigm, and (3) repeated training causes lasting reduction in VOR gain asymmetry. |
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Authors:
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Munetaka Ushio; Lloyd B Minor; Charles C Della Santina; David M Lasker |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-03-23 |
Journal Detail:
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Title: Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale Volume: 210 ISSN: 1432-1106 ISO Abbreviation: Exp Brain Res Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-13 Completed Date: 2011-08-04 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 0043312 Medline TA: Exp Brain Res Country: Germany |
Other Details:
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Languages: eng Pagination: 651-60 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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physiology* Animals Eye Movements Functional Laterality / physiology* Macaca Reflex, Vestibulo-Ocular / physiology* Rotation* Time Factors Vestibule, Labyrinth / physiology*, surgery |
| Grant Support | |
ID/Acronym/Agency:
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R01 DC002390-16A1/DC/NIDCD NIH HHS; R01 DC009255/DC/NIDCD NIH HHS; R01 DC009255-04/DC/NIDCD NIH HHS; R01 DC009255-05/DC/NIDCD NIH HHS; R01 DC02390/DC/NIDCD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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