| Unfractionated heparin and low-molecular-weight heparin for the initial treatment of acute venous thromboembolism. | |
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MedLine Citation:
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PMID: 10069766 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anticoagulant drugs represent the therapy of choice for the initial treatment of venous thromboembolism. Unfractionated heparin (UFH) in adjusted doses and low-molecular-weight heparin (LMWH) in fixed doses are equally as effective and safe. Proper use of UFH requires considerable expertise, can cause inconvenience and has limitations. The use of LMWHs has multiple advantages over UFH including a more predictable dose-response and fixed administration dose. These properties make the treatment of suitable patients feasible in an outpatient setting. In two major clinical trials addressing the treatment of deep vein thrombosis, outpatient management with LMWH was associated with a substantial cost reduction compared with inpatient treatment using UFH. Recent studies have also shown that LMWHs are at least as effective and safe as UFH for the treatment of non-critical patients with pulmonary embolism. Whether or not home treatment of pulmonary embolism is feasible and safe remains to be demonstrated. |
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Authors:
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P Prandoni |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Haemostasis Volume: 28 Suppl 3 ISSN: 0301-0147 ISO Abbreviation: Haemostasis Publication Date: 1998 |
Date Detail:
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Created Date: 1999-06-01 Completed Date: 1999-06-01 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0371574 Medline TA: Haemostasis Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 85-90 Citation Subset: IM |
Affiliation:
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Institute of Medical Semeiotics, University of Padua, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Heparin / therapeutic use* Heparin, Low-Molecular-Weight / therapeutic use* Humans Outpatients Venous Thrombosis / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Heparin, Low-Molecular-Weight; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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