Document Detail

Unfavorable outcome of adrenal medullary transplant for Parkinson's disease.
MedLine Citation:
PMID:  1882645     Owner:  NLM     Status:  MEDLINE    
A 45-year-old woman with moderately severe parkinsonism underwent adrenal medullary autograft to the brain. The operation was performed in Mexico City. There were multiple post-operative complications, including worsening of the parkinsonism with almost complete loss of ability to communicate. Death from bronchopneumonia occurred 13 months after surgery. At autopsy the surgical tract was found to extend through the corpus callosum and into the thalamus on the opposite side. Residual necrotic adrenal tissue was found as a small round well-defined mass in the ventricle loosely attached to the left fornix. This case emphasizes the obvious risks of this still experimental procedure and the difficulties in obtaining a surviving and functional adrenal medullary graft.
L S Forno; J W Langston
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Acta neuropathologica     Volume:  81     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  1991  
Date Detail:
Created Date:  1991-10-03     Completed Date:  1991-10-03     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  691-4     Citation Subset:  IM    
Department of Pathology, VA Medical Center, Palo Alto, CA.
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MeSH Terms
Adrenal Medulla / transplantation*
Brain / pathology
Middle Aged
Parkinson Disease / pathology,  surgery*
Postoperative Complications*
Transplantation, Homologous

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