Document Detail

Unexplained elevated maternal serum beta-HCG concentration and adverse pregnancy outcome.
MedLine Citation:
PMID:  17621365     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the association between unexplained elevated maternal serum beta-Human chorionic gonadotrophin (HCG) in the second trimester of pregnancy and adverse pregnancy outcome. METHODS: In a case-controlled study of 3463 women who opted for second-trimester serum screening for Down syndrome, 142 were found to have a serum beta-HCG of > or =3.5 multiples of the median (MoM), 56 of whom had a serum beta-HCG of > or =5.0 MoM. These women were compared with a control group of women with serum beta-HCG within the 95% confidence interval around the median. RESULTS: In the elevated beta-HCG group (> or =5 MoM) significantly more babies required admission to the special care baby unit (p = 0.02) and were small for gestational age (SGA) (p = 0.03). The mean birth weight was also significantly lower in the group with elevated beta-HCG. Women with a serum beta-HCG of > or =5, > or =6, > or =7 or > or =8 MoM were associated with SGA babies in 40, 44, 64 and 86% respectively. All babies born to the six women with beta-HCG of 8.75-24.1 MoM were SGA. CONCLUSION: Increased surveillance is necessary in pregnancies where the maternal serum beta-HCG in the second trimester is inexplicably elevated to > or =5 MoM.
Ramesh Ganapathy; Ronald F Lamont; Paul Bassett
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  27     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-29     Completed Date:  2008-02-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  995-9     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Northwick Park Hospital, North-West London, NHS Trust, London, UK.
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MeSH Terms
Case-Control Studies
Chorionic Gonadotropin, beta Subunit, Human / blood*
Infant, Newborn
Infant, Small for Gestational Age
Pregnancy Complications / blood*,  diagnosis,  epidemiology
Pregnancy Outcome*
Pregnancy Trimester, Second
Prenatal Diagnosis
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human

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