| Unexplained elevated maternal serum beta-HCG concentration and adverse pregnancy outcome. | |
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MedLine Citation:
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PMID: 17621365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the association between unexplained elevated maternal serum beta-Human chorionic gonadotrophin (HCG) in the second trimester of pregnancy and adverse pregnancy outcome. METHODS: In a case-controlled study of 3463 women who opted for second-trimester serum screening for Down syndrome, 142 were found to have a serum beta-HCG of > or =3.5 multiples of the median (MoM), 56 of whom had a serum beta-HCG of > or =5.0 MoM. These women were compared with a control group of women with serum beta-HCG within the 95% confidence interval around the median. RESULTS: In the elevated beta-HCG group (> or =5 MoM) significantly more babies required admission to the special care baby unit (p = 0.02) and were small for gestational age (SGA) (p = 0.03). The mean birth weight was also significantly lower in the group with elevated beta-HCG. Women with a serum beta-HCG of > or =5, > or =6, > or =7 or > or =8 MoM were associated with SGA babies in 40, 44, 64 and 86% respectively. All babies born to the six women with beta-HCG of 8.75-24.1 MoM were SGA. CONCLUSION: Increased surveillance is necessary in pregnancies where the maternal serum beta-HCG in the second trimester is inexplicably elevated to > or =5 MoM. |
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Authors:
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Ramesh Ganapathy; Ronald F Lamont; Paul Bassett |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 27 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-29 Completed Date: 2008-02-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 995-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, Northwick Park Hospital, North-West London, NHS Trust, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Chorionic Gonadotropin, beta Subunit, Human / blood* Female Humans Incidence Infant, Newborn Infant, Small for Gestational Age Mothers* Pregnancy Pregnancy Complications / blood*, diagnosis, epidemiology Pregnancy Outcome* Pregnancy Trimester, Second Prenatal Diagnosis |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin, beta Subunit, Human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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