Document Detail


Unexplained elevated maternal serum alpha-fetoprotein in singleton pregnancies as a predictor of fetal risk.
MedLine Citation:
PMID:  8737299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The aim of the study was to evaluate the significance of unexplained elevated maternal serum alpha-fetoprotein in singleton pregnancies as a predictor of fetal risk. METHOD: A retrospective study of 1582 consecutive women who attended the antenatal clinic at Oldham and District General Hospital, Oldham, UK, over a 6-month period. One hundred pregnant women with elevated serum alpha-fetoprotein concentrations were classified as the index group and were matched against a control group. All the women in the index group underwent amniocentesis and detailed ultrasonography. The incidence of antepartum hemorrhage (placental abruption and placenta previa), preterm labor and intrauterine growth restriction (IUGR) in the two groups was analyzed and the results subjected to X2 analysis. RESULTS: None of the patients in the index group had chromosomal abnormalities or birth defects. IUGR occurred in 18 (18%) of the index group babies but in only four (2%) in the control group (P < 0.0000006). Placental abruption occurred in five (5%) in the index group compared with two (2%) in the control group (P < 0.03), while preterm labor occurred in nine (9%) in the index group compared with two (2%) in the control group (P < 0.005). CONCLUSION: Women with unexplained elevated maternal serum alpha-fetoprotein are at increased risk of preterm labor, antepartum hemorrhage (placental abruption) and IUGR.
Authors:
A A Akinbiyi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  53     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-09-27     Completed Date:  1996-09-27     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  17-21     Citation Subset:  IM    
Affiliation:
Oldham and District General Hospital, UK.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Biological Markers / blood
Female
Fetal Growth Retardation / blood
Humans
Middle Aged
Obstetric Labor, Premature / blood
Pregnancy
Pregnancy Trimester, Second
Pregnancy, High-Risk / blood*
Retrospective Studies
Uterine Hemorrhage / blood
alpha-Fetoproteins / analysis*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/alpha-Fetoproteins

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