Document Detail

Unexplained elevated maternal serum alpha-fetoprotein levels and perinatal outcome in an urban clinic population.
MedLine Citation:
PMID:  7524321     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose was to determine whether obstetric patients with unexplained elevated maternal serum alpha-fetoprotein levels from an indigent clinic population are at increased risk for adverse perinatal outcome compared with similar patients with normal values. STUDY DESIGN: Perinatal outcomes from inner-city obstetric patients with unexplained elevated maternal serum alpha-fetoprotein levels (> 2.0 multiples of the median) were compared with patients from the same clinic with normal values. The frequency of adverse outcomes in the two groups was subjected to chi 2 analysis. RESULTS: Adverse perinatal outcomes occurred in 33 of 57 (58%) of the subjects with unexplained elevated maternal serum alpha-fetoprotein levels compared with 163 of 719 (23%) patients with normal values (p < 0.001). Statistically significant differences were observed for abruptio placentae (p < 0.025), intrauterine growth retardation (p < 0.025), stillbirth at > 20 weeks (p < 0.001), and pregnancy-induced hypertension (p < 0.01). Differences in the frequencies of preterm premature rupture of membranes, preterm delivery, pregnancy loss < 20 weeks, and congenital malformations were not statistically significant. CONCLUSION: In contrast to a previous report, we found that unexplained elevated maternal serum alpha-fetoprotein levels confer an increased risk of adverse perinatal outcome in an urban clinic population over and above the already increased risk related to socioeconomic status.
W F Brazerol; S Grover; A E Donnenfeld
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  171     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1994-11-15     Completed Date:  1994-11-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1030-5     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Pennsylvania Hospital, Philadelphia 19107.
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MeSH Terms
Abruptio Placentae / epidemiology
Ambulatory Care Facilities
Chi-Square Distribution
Cohort Studies
Fetal Death / epidemiology
Fetal Growth Retardation / epidemiology
Hypertension / epidemiology
Pregnancy / blood*
Pregnancy Complications, Cardiovascular / epidemiology
Pregnancy Outcome*
Risk Factors
Socioeconomic Factors
Urban Health
alpha-Fetoproteins / metabolism*
Reg. No./Substance:

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