| Unexplained elevated maternal serum alpha-fetoprotein levels and perinatal outcome in an urban clinic population. | |
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MedLine Citation:
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PMID: 7524321 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Our purpose was to determine whether obstetric patients with unexplained elevated maternal serum alpha-fetoprotein levels from an indigent clinic population are at increased risk for adverse perinatal outcome compared with similar patients with normal values. STUDY DESIGN: Perinatal outcomes from inner-city obstetric patients with unexplained elevated maternal serum alpha-fetoprotein levels (> 2.0 multiples of the median) were compared with patients from the same clinic with normal values. The frequency of adverse outcomes in the two groups was subjected to chi 2 analysis. RESULTS: Adverse perinatal outcomes occurred in 33 of 57 (58%) of the subjects with unexplained elevated maternal serum alpha-fetoprotein levels compared with 163 of 719 (23%) patients with normal values (p < 0.001). Statistically significant differences were observed for abruptio placentae (p < 0.025), intrauterine growth retardation (p < 0.025), stillbirth at > 20 weeks (p < 0.001), and pregnancy-induced hypertension (p < 0.01). Differences in the frequencies of preterm premature rupture of membranes, preterm delivery, pregnancy loss < 20 weeks, and congenital malformations were not statistically significant. CONCLUSION: In contrast to a previous report, we found that unexplained elevated maternal serum alpha-fetoprotein levels confer an increased risk of adverse perinatal outcome in an urban clinic population over and above the already increased risk related to socioeconomic status. |
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Authors:
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W F Brazerol; S Grover; A E Donnenfeld |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 171 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1994 Oct |
Date Detail:
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Created Date: 1994-11-15 Completed Date: 1994-11-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1030-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Pennsylvania Hospital, Philadelphia 19107. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abruptio Placentae
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epidemiology Adolescent Adult Ambulatory Care Facilities Chi-Square Distribution Cohort Studies Female Fetal Death / epidemiology Fetal Growth Retardation / epidemiology Humans Hypertension / epidemiology Pregnancy / blood* Pregnancy Complications, Cardiovascular / epidemiology Pregnancy Outcome* Risk Factors Socioeconomic Factors Urban Health alpha-Fetoproteins / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/alpha-Fetoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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