| Unexplained amenorrhea in a patient taking methotrexate for the treatment of rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 19916871 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The cause of secondary amenorrhea in the following case cannot be explained by traditional etiologies. We therefore questioned whether long-term methotrexate treatment played a role as an endometrial inhibitor. CASE: A 44-year-old G4P2, with a 5-year history of rheumatoid arthritis, presented with a 2-year history of secondary amenorrhea. The patient took methotrexate since diagnosis. Her FSH, estrogen, prolactin, TSH and T4 levels were normal, her B-HCG was negative, her BMI was 22 and she had no history of Asherman's syndrome. CONCLUSION: There is no information, based on our search, on whether long-term methotrexate treatment has an effect on the menstrual cycle. This case highlights the need for the elucidation of the effects of long-term methotrexate treatment on the menstrual cycle in patients with rheumatoid arthritis. |
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Authors:
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Jamie Kroft; Sally Sabra; Rebecca Arthur; Wendy Wolfman |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 26 ISSN: 1473-0766 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-12 Completed Date: 2010-10-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 179-80 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, 700 University Avenue, Toronto, Ontario, Canada. jamie.kroft@utoronto.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amenorrhea / chemically induced* Antirheumatic Agents / adverse effects*, therapeutic use* Arthritis, Rheumatoid / drug therapy* Female Humans Methotrexate / adverse effects*, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antirheumatic Agents; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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