Document Detail

Unexpected recovery in a newborn with severe hypomyelinating neuropathy.
MedLine Citation:
PMID:  9165518     Owner:  NLM     Status:  MEDLINE    
We report the case of a severely hypotonic and weak term newborn who required ventilatory support from the time of birth. Serial neurophysiologic studies were consistent with severe demyelinating polyneuropathy. The infant's condition deteriorated over several weeks despite treatment with corticosteroids and intravenous immunoglobulin (IVIG) for presumed inflammatory demyelinating polyneuropathy. Histopathologic findings in a sural nerve biopsy, however, were similar to those previously reported in congenital hypomyelinating neuropathies. After 12 weeks of hospitalization and after discontinuation of corticosteroids, the patient began to recover and required no further ventilatory support. Remarkable improvement has continued for 18 months. This patient raises questions about the underlying mechanisms of hypomyelinating neuropathies in early infancy.
B K Levy; G A Fenton; S Loaiza; G R Hayat
Related Documents :
14717428 - Vascular ring in an extremely low birth weight infant.
10228288 - Short versus prolonged indomethacin therapy for patent ductus arteriosus in preterm inf...
15843268 - Comparison of clinical criteria with echocardiographic findings in diagnosing pda in pr...
3948448 - Noninvasive assessment of indomethacin therapy in patent ductus arteriosus in preterm i...
2741868 - Postmortem pink teeth. histochemical identification of the causative pigment.
138398 - Cutaneous and hepatic haemangiomata.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric neurology     Volume:  16     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-07-17     Completed Date:  1997-07-17     Revised Date:  2006-05-23    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  245-8     Citation Subset:  IM    
Department of Neurology, St. Louis University School of Medicine, Missouri, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Demyelinating Diseases / pathology,  physiopathology*,  therapy
Immunoglobulins, Intravenous / therapeutic use
Infant, Newborn
Infant, Newborn, Diseases / pathology,  physiopathology*,  therapy
Peripheral Nervous System Diseases / pathology,  physiopathology*,  therapy
Remission, Spontaneous
Sural Nerve / pathology
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Immunoglobulins, Intravenous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Encephalomyelitis subsequent to mycoplasma infection with elevated serum anti-Gal C antibody.
Next Document:  Bilateral tonic-clonic epileptic seizures in non-benign familial neonatal convulsions.