Document Detail

Unexpected mobilisation of lead during cisplatin chemotherapy.
MedLine Citation:
PMID:  2874280     Owner:  NLM     Status:  MEDLINE    
During an investigation by X-ray fluorescence of platinum uptake in the kidney after chemotherapy with cisplatin, lead was found to have accumulated in the kidney in four subjects. The average kidney lead burden in one case exceeded 800 micrograms/g. Although two of the subjects had been occupationally exposed to lead, the other two had not. The tibia lead burden was also high in the two subjects in whom it was measured. The origins of this mobilised lead and the implications for cisplatin nephrotoxicity are discussed.
A M el-Sharkawi; W D Morgan; S Cobbold; M B Jaib; C J Evans; L J Somervaille; D R Chettle; M C Scott
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  249-50     Citation Subset:  AIM; IM    
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MeSH Terms
Body Burden
Bone and Bones / metabolism
Cisplatin / adverse effects*,  metabolism
Environmental Exposure
Kidney / metabolism
Lead / metabolism*
Middle Aged
Pilot Projects
Platinum / metabolism
Reg. No./Substance:
15663-27-1/Cisplatin; 7439-92-1/Lead; 7440-06-4/Platinum
Comment In:
Lancet. 1989 Aug 5;2(8658):333   [PMID:  2569135 ]

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