| Unexpected fabry disease in a renal allograft kidney: an underrecognized cause of poor allograft function. | |
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MedLine Citation:
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PMID: 21299350 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Fabry disease is an X-linked recessive lysosomal storage disease caused by a deficiency of ?-galactosidase A, with characteristic ultrastructural cytoplasmic myelin-like inclusions. Renal lesions are seen in male and variably in heterozygous female patients. One previous report has described Fabry disease involving a renal allograft from a deceased female donor with no history of Fabry disease. The authors describe another case, in which suspicion for Fabry disease was raised ultrastructurally. This serves as a reminder that proteinuria after renal transplantation may be due to donor-derived disease. Fabry disease is probably an underrecognized cause of graft dysfunction. This case provides further justification for ultrastructural examination of renal allograft biopsies. |
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Authors:
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Olga Kochar; Mark R Wick; Sarah E Kerr; Devin Oglesbee; Helen P Cathro |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ultrastructural pathology Volume: 35 ISSN: 1521-0758 ISO Abbreviation: Ultrastruct Pathol Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-02-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8002867 Medline TA: Ultrastruct Pathol Country: England |
Other Details:
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Languages: eng Pagination: 92-6 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, University of Virginia, Charlottesville, Virginia, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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