Document Detail

Unexpected doxorubicin-mediated cardiotoxicity in sisters: possible role of polymorphisms in histamine n-methyl transferase.
MedLine Citation:
PMID:  23154571     Owner:  NLM     Status:  MEDLINE    
The anthracycline anticancer agent doxorubicin has long been recognized to induce a dose-limiting cardiotoxicity and may be associated with genes relevant to doxorubicin disposition. Recent reports suggest a role for a number of single nucleotide polymorphisms in anthracycline cardiotoxicity in children. We describe two adult sisters with anthracycline cardiotoxicity that developed after a relatively low dose of doxorubicin. One sister carried the variant genotype for histamine N-ethyl transferase (HNMT, rs17583889) while the other was heterozygous, suggesting a similar role for these genotypes in adults with anthracycline cardiotoxicity. Although this requires further study, these genotypes may be important in the clinical dosing, or use of the liposomal formulation of doxorubicin.
Kamakshi Sachidanandam; Arlene A Gayle; H Ian Robins; Jill M Kolesar
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-15
Journal Detail:
Title:  Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners     Volume:  19     ISSN:  1477-092X     ISO Abbreviation:  J Oncol Pharm Pract     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-13     Completed Date:  2014-04-24     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  9511372     Medline TA:  J Oncol Pharm Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  269-72     Citation Subset:  IM    
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MeSH Terms
Antibiotics, Antineoplastic / adverse effects*
Cardiotoxins / adverse effects*
Doxorubicin / adverse effects*
Heart Diseases / chemically induced*,  enzymology*,  genetics
Histamine N-Methyltransferase / genetics*
Polymorphism, Single Nucleotide
Grant Support
P30 CA014520/CA/NCI NIH HHS; P30 CA014520/CA/NCI NIH HHS
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Cardiotoxins; 80168379AG/Doxorubicin; EC N-Methyltransferase

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