| Unexpected extra-renal effects of loop diuretics in the preterm neonate. | |
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MedLine Citation:
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PMID: 22536874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The loop diuretics furosemide and bumetanide are commonly used in neonatal intensive care units (NICUs). Furosemide, because of its actions on the ubiquitous Na(+) -K(+) -2Cl(-) isoform cotransporter and its promotion of prostanoid production and release, also has non-diuretic effects on vascular smooth muscle, airways, the ductus arteriosus and theoretically the gastrointestinal tract. Loop diuretics also affect the central nervous system through modulation of the GABA-A chloride channel. Conclusion: The loop diuretics have a variety of biological effects that are potentially harmful as well as beneficial. Care should be taken with the use of these agents because the range of their effects may be broader than the single action sought by the prescribing physician. |
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Authors:
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Robert Cotton; Sandra Suarez; Jeff Reese |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2012-05-28 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 101 ISSN: 1651-2227 ISO Abbreviation: Acta Paediatr. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-07-13 Completed Date: 2012-11-05 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 835-45 Citation Subset: IM |
Copyright Information:
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© 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica. |
Affiliation:
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Department of Pediatrics, Division of Neonatology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. robert.cotton@vanderbilt.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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metabolism Bronchopulmonary Dysplasia / drug therapy Bumetanide / pharmacology*, therapeutic use Central Nervous System / drug effects, metabolism Diuretics / pharmacology*, therapeutic use Ductus Arteriosus / drug effects Furosemide / pharmacology*, therapeutic use Gastrointestinal Tract / drug effects Humans Hyaline Membrane Disease / drug therapy Infant, Newborn Infant, Premature* Intensive Care, Neonatal* Lung / drug effects Muscle, Smooth, Vascular / drug effects gamma-Aminobutyric Acid / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HL109199/HL/NHLBI NIH HHS; HL77395/HL/NHLBI NIH HHS; HL96967/HL/NHLBI NIH HHS; R01 HL077395-05/HL/NHLBI NIH HHS; R01 HL096967/HL/NHLBI NIH HHS; R01 HL096967-04/HL/NHLBI NIH HHS; R01 HL109199-02/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Diuretics; 28395-03-1/Bumetanide; 54-31-9/Furosemide; 56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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