| Uneventful cesarean delivery with administration of factor XI concentrate in a patient with severe factor XI deficiency. | |
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MedLine Citation:
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PMID: 17988987 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Factor XI (FXI) is a procoagulant factor and antifibrinolytic agent, and its absence causes a bleeding tendency. FXI deficiency is autosomal in inheritance, with severe FXI deficiency in homozygotes and partial deficiency in heterozygotes. A 24-year-old primigravida with an uneventful pregnancy and no history of bleeding manifestations was admitted to our department at 38 weeks of gestation. Her blood count and serum biochemistry findings were normal except for a coagulation screen, which revealed a prolonged activated partial thromboplastin time (APTT) of 63 seconds (normal range, 24-35 seconds). The measured FXI coagulant activity of 8 IU/dL (reference range, 70-150 IU/dL) established a diagnosis of severe FXI deficiency. The breech presentation of the fetus prompted the decision for cesarean delivery under general anesthesia. We administered a single dose of FXI concentrate (15 IU/kg), which corrected the APTT to 34 seconds. The cesarean delivery was uncomplicated, and postpartum recovery of the mother and her baby was uneventful with no bleeding complications. The finding of an isolated prolonged APTT should prompt obstetricians to consider FXI deficiency. The appropriate use of factor FXI concentrate in managing obstetric patients with FXI deficiency can minimize potential bleeding complications and ensure an optimal outcome for both mother and neonate. |
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Authors:
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Georgios Mavromatidis; Konstantinos Dinas; Dimitrios Delkos; Fotios Goutzioulis; Christos Vosnakis; Emmanouel Hatzipantelis; Vassilia Garipidou; David Rousso |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of hematology Volume: 86 ISSN: 0925-5710 ISO Abbreviation: Int. J. Hematol. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-11-08 Completed Date: 2007-12-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111627 Medline TA: Int J Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 222-4 Citation Subset: IM |
Affiliation:
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Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Loss, Surgical / prevention & control Cesarean Section* Factor XI / administration & dosage*, analysis Factor XI Deficiency / blood, drug therapy* Female Hemorrhage / blood, prevention & control Humans Live Birth Pregnancy Pregnancy Complications, Hematologic / blood, drug therapy* |
| Chemical | |
Reg. No./Substance:
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9013-55-2/Factor XI |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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