Document Detail


Uneven deficits in vertebral bone density in postmenopausal patients with primary hyperparathyroidism as evaluated by posterior-anterior and lateral dual-energy absorptiometry.
MedLine Citation:
PMID:  12181619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This investigation was undertaken to determine whether the preservation of bone mass in patients with mild primary hyperparathyroidism (PHPT) could be detected when measuring spine density in the lateral projection. We compared the bone mineral density (BMD) of L2-L4 utilizing the posterior-anterior (PA) and lateral projections in postmenopausal patients with PHPT and in a group of 27 postmenopausal normal women. Thirty-three consecutive postmenopausal patients with PHPT were studied; 25 were asymptomatic whereas the remaining 8 suffered complications related to the disease. Based upon the criteria established by the Consensus Conference on the Management of Asymptomatic PHPT, only 10 of the 25 asymptomatic patients could be considered affected by mild disease; the remaining patients were classified as having moderate disease. Patients with mild disease had mean lateral total BMD values (0.682 +/- 0.113 g/cm(2)) significantly higher than normal women (0.588 +/- 0.076, p<0.02) and patients with moderate disease (0.599 +/- 0.077, p<0.05). There were significant differences among the three groups in both PA L2-L4 and L1-L4 levels: patients with mild disease had significantly higher mean BMD values than patients with moderate disease and normal women, when either three or four vertebrae were considered. Interestingly, at this latter site, patients with moderate disease had significantly ( p<0.05) lower values than normal women. Our results indicate that patients with mild PHPT have a preservation of vertebral mass when compared with the other hyperparathyroid patients and normal women, when taking into account both the mainly trabecular portion and the whole vertebra. The finding that when the PA projection was assessed, BMD values of patients with moderate disease were significantly lower than those of normal women, might be attributed to the detrimental effect of raised parathyroid hormone levels on the cortical component of the vertebral body.
Authors:
S Minisola; R Rosso; E Romagnoli; J Pepe; S De Geronimo; S Dionisi; F Paglia; N Raejntroph; G Aliberti; G F Mazzuoli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA     Volume:  13     ISSN:  0937-941X     ISO Abbreviation:  Osteoporos Int     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-15     Completed Date:  2002-10-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9100105     Medline TA:  Osteoporos Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  618-23     Citation Subset:  IM    
Affiliation:
Dipartimento di Scienze Cliniche, Università La Sapienza, Rome. salvatore.minisola@uniroma1.it
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MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon / methods
Aged
Analysis of Variance
Bone Density*
Calcium / blood
Case-Control Studies
Female
Humans
Hyperparathyroidism / blood,  physiopathology*
Lumbar Vertebrae / physiology
Middle Aged
Osteoporosis / physiopathology*,  radiography
Parathyroid Hormone / physiology
Postmenopause / blood,  physiology*
Chemical
Reg. No./Substance:
0/Parathyroid Hormone; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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