Document Detail


Unequally redundant RCD1 and SRO1 mediate stress and developmental responses and interact with transcription factors.
MedLine Citation:
PMID:  19548978     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RADICAL-INDUCED CELL DEATH1 (RCD1) is an important regulator of stress and hormonal and developmental responses in Arabidopsis thaliana. Together with its closest homolog, SIMILAR TO RCD-ONE1 (SRO1), it is the only Arabidopsis protein containing the WWE domain, which is known to mediate protein-protein interactions in other organisms. Additionally, these two proteins contain the core catalytic region of poly-ADP-ribose transferases and a conserved C-terminal domain. Tissue and subcellular localization data indicate that RCD1 and SRO1 have partially overlapping functions in plant development. In contrast mutant data indicate that rcd1 has defects in plant development, whereas sro1 displays normal development. However, the rcd1 sro1 double mutant has severe growth defects, indicating that RCD1 and SRO1 exemplify an important genetic principle - unequal genetic redundancy. A large pair-wise interaction test against the REGIA transcription factor collection revealed that RCD1 interacts with a large number of transcription factors belonging to several protein families, such as AP2/ERF, NAC and basic helix-loop-helix (bHLH), and that SRO1 interacts with a smaller subset of these. Full genome array analysis indicated that in many cases targets of these transcription factors have altered expression in the rcd1 but not the sro1 mutant. Taken together RCD1 and SRO1 are required for proper plant development.
Authors:
Pinja Jaspers; Tiina Blomster; Mikael Brosché; Jarkko Salojärvi; Reetta Ahlfors; Julia P Vainonen; Ramesha A Reddy; Richard Immink; Gerco Angenent; Franziska Turck; Kirk Overmyer; Jaakko Kangasjärvi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-22
Journal Detail:
Title:  The Plant journal : for cell and molecular biology     Volume:  60     ISSN:  1365-313X     ISO Abbreviation:  Plant J.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-14     Completed Date:  2009-12-02     Revised Date:  2011-04-26    
Medline Journal Info:
Nlm Unique ID:  9207397     Medline TA:  Plant J     Country:  England    
Other Details:
Languages:  eng     Pagination:  268-79     Citation Subset:  IM    
Affiliation:
Plant Biology, Department of Biological and Environmental Sciences, Viikki Biocenter, University of Helsinki, Helsinki, Finland.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Arabidopsis / genetics*,  growth & development,  metabolism
Arabidopsis Proteins / genetics,  metabolism*
Gene Expression Regulation, Developmental
Gene Expression Regulation, Plant
Genome, Plant
Molecular Sequence Data
Mutation
Nuclear Proteins / genetics,  metabolism*
Oligonucleotide Array Sequence Analysis
Plants, Genetically Modified / genetics,  growth & development,  metabolism
Promoter Regions, Genetic
RNA, Plant / genetics
Sequence Alignment
Stress, Physiological
Transcription Factors / metabolism*
Chemical
Reg. No./Substance:
0/Arabidopsis Proteins; 0/Nuclear Proteins; 0/RCD1 protein, Arabidopsis; 0/RNA, Plant; 0/SRO1 protein, Arabidopsis; 0/Transcription Factors
Comments/Corrections
Comment In:
Plant Signal Behav. 2010 Jan;5(1):78-80   [PMID:  20592818 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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