| Undiluted N-butyl cyanoacrylate is safe and effective for gastric variceal bleeding. | |
| | |
MedLine Citation:
|
PMID: 20883849 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND: Gastric variceal bleeding is associated with significant morbidity and mortality in patients with portal hypertension. N-butyl cyanoacrylate (NBC), mixed with lipiodol, has been shown to be effective in controlling bleeding, but is associated with the risk of distal embolization. OBJECTIVE: To study the efficacy and safety of undiluted NBC in the management of gastric varices (GV). DESIGN: Prospective cohort study. SETTING: Single tertiary care center. PATIENTS: 170 consecutive patients with GV. INTERVENTION: Standardized technique of undiluted NBC injection for management of GV. MAIN OUTCOME MEASUREMENTS: Achievement of initial hemostasis, rate of rebleeding, procedure-related complications, and mortality. RESULTS: GV were identified in 170 patients, 87 of whom were treated with 261 injections of undiluted NBC. Among 46 patients with active bleeding of GV, initial hemostasis was achieved in 84.8%. Rebleeding was seen in 23.4% patients over a mean follow-up of 16 months. No case of clinical distal embolization was seen. Large GV size, fundal location, and large esophageal variceal size were predictive of GV bleed. The mortality was 8.8% for all patients with GV; 10.3% for patients with GV treated with NBC, and 7.2% for those with GV not treated with NBC. Child-Pugh status was the only predictor of mortality. LIMITATION: Only 1 intervention group. CONCLUSION: Undiluted NBC is safe and effective in the management of gastric variceal bleeding. |
| | |
Authors:
|
Ajay Kumar; Siddharth Singh; Kaushal Madan; Pramod Kumar Garg; Subrat Kumar Acharya |
Related Documents
:
|
10208199 - Immediate and long-term results of bronchial artery embolization for life-threatening h... 2312049 - Recurrence factors studied by percutaneous transhepatic portography before and after en... 15966239 - The treatment of gastric fundal varices--endoscopic therapy versus interventional radio... 15247089 - Cirrhosis progression as a model of accelerated senescence: affecting the biological ag... 15937649 - P450 enzyme inducing and non-enzyme inducing antiepileptics in glioblastoma patients tr... 1363889 - Management of variceal haemorrhage. 10457249 - The effect of foot massage on patients' perception of care following laparoscopic steri... 21680139 - High-flex posterior cruciate-retaining vs posterior cruciate-substituting designs in si... 8310769 - Postocclusive reactive hyperemia and postural vasoconstriction in different kinds of le... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Gastrointestinal endoscopy Volume: 72 ISSN: 1097-6779 ISO Abbreviation: Gastrointest. Endosc. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-04 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0010505 Medline TA: Gastrointest Endosc Country: United States |
Other Details:
|
Languages: eng Pagination: 721-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved. |
Affiliation:
|
Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Use of a fully covered self-expandable metal stent for the treatment of benign esophageal diseases.
Next Document: Prediction of drainage effectiveness during endoscopic stenting of malignant hilar strictures: the r...