| Undifferentiated sarcoma of the liver in childhood: morphology, flow cytometry, and literature review. | |
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MedLine Citation:
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PMID: 2403976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nine cases of undifferentiated sarcoma of the liver in childhood were investigated by conventional light microscopy, immunohistochemistry, and DNA flow cytometry. Different histologic patterns were discernible. In some cases, areas resembling poorly differentiated rhabdomyosarcoma were present. This histologic diversity was supported by the immunohistologic detection of desmin and cytokeratins in five cases. When evaluated by flow cytometry, four of five cases investigated were diploid; only one was aneuploid, and this patient had the most aggressive course. Follow-up investigations of our patients and those described in the literature revealed that the prognosis of this type of tumor is not as bad as is generally assumed. Of the patients reported in the literature with detailed follow-up information, 37.5% survived without evidence of disease for an average of 37.5 months, death occurred in 47.5% after an average of 11.9 months, and 15.0% were alive with disease. |
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Authors:
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I Leuschner; D Schmidt; D Harms |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Human pathology Volume: 21 ISSN: 0046-8177 ISO Abbreviation: Hum. Pathol. Publication Date: 1990 Jan |
Date Detail:
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Created Date: 1990-02-21 Completed Date: 1990-02-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421547 Medline TA: Hum Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 68-76 Citation Subset: IM |
Affiliation:
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Institut für Pathologie, Universität Kiel, FRG. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Child, Preschool Cytoskeletal Proteins / analysis DNA, Neoplasm / analysis Female Flow Cytometry Humans Immunohistochemistry Liver Neoplasms / genetics, metabolism, pathology* Male Sarcoma / genetics, metabolism, pathology* alpha 1-Antitrypsin / analysis |
| Chemical | |
Reg. No./Substance:
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0/Cytoskeletal Proteins; 0/DNA, Neoplasm; 0/alpha 1-Antitrypsin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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