Document Detail


Undifferentiated sarcoma of the liver in childhood: morphology, flow cytometry, and literature review.
MedLine Citation:
PMID:  2403976     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nine cases of undifferentiated sarcoma of the liver in childhood were investigated by conventional light microscopy, immunohistochemistry, and DNA flow cytometry. Different histologic patterns were discernible. In some cases, areas resembling poorly differentiated rhabdomyosarcoma were present. This histologic diversity was supported by the immunohistologic detection of desmin and cytokeratins in five cases. When evaluated by flow cytometry, four of five cases investigated were diploid; only one was aneuploid, and this patient had the most aggressive course. Follow-up investigations of our patients and those described in the literature revealed that the prognosis of this type of tumor is not as bad as is generally assumed. Of the patients reported in the literature with detailed follow-up information, 37.5% survived without evidence of disease for an average of 37.5 months, death occurred in 47.5% after an average of 11.9 months, and 15.0% were alive with disease.
Authors:
I Leuschner; D Schmidt; D Harms
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Human pathology     Volume:  21     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-21     Completed Date:  1990-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  68-76     Citation Subset:  IM    
Affiliation:
Institut für Pathologie, Universität Kiel, FRG.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Child, Preschool
Cytoskeletal Proteins / analysis
DNA, Neoplasm / analysis
Female
Flow Cytometry
Humans
Immunohistochemistry
Liver Neoplasms / genetics,  metabolism,  pathology*
Male
Sarcoma / genetics,  metabolism,  pathology*
alpha 1-Antitrypsin / analysis
Chemical
Reg. No./Substance:
0/Cytoskeletal Proteins; 0/DNA, Neoplasm; 0/alpha 1-Antitrypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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