Document Detail

Undifferentiated connective tissue disease: a seven-center cross-sectional study of 184 patients.
MedLine Citation:
PMID:  19390908     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to characterize the clinical and serological features of a large cohort of patients with antinuclear antibody (ANA) positive undifferentiated connective tissue disease (UCTD). Consecutive patients with UCTD, followed up at the Rheumatology Clinic of the participating centers, were included. Data from these patients were obtained by clinical evaluation and chart review. All patients were diagnosed as having UCTD on basis of the following criteria: positive ANA plus at least one clinical feature of connective tissue disease, but not fulfilling classification criteria for any differentiated connective tissue disease. One hundred eighty-four patients were studied (female patients-94.5%; mean age at time of evaluation-47 years). The most prevalent manifestations were arthralgia (66%), arthritis (32%), Raynaud's phenomenon (30%), sicca symptoms (30%), and leukopenia (19%). The prevalence of ANA was 100%, anti-SSA 20%, anti-dsDNA 14%, and anti-SSB 7%. Patients with anti-dsDNA/anti-Sm, anticentromere/anti-Scl70, or anti-SSA/anti-SSB antibodies more frequently presented a set of manifestations close to systemic lupus erythematosus (SLE), systemic sclerosis, or Sjögren syndrome, respectively. We analyze a large cohort of UCTD. Seventy-two percent of these UCTD patients present lupus-, scleroderma-, or Sjögren-like features but do not fulfill classification criteria and mostly present a mild disease.
C C Vaz; M Couto; D Medeiros; L Miranda; J Costa; P Nero; R Barros; M J Santos; E Sousa; A Barcelos; L Inês
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2009-04-24
Journal Detail:
Title:  Clinical rheumatology     Volume:  28     ISSN:  1434-9949     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-17     Completed Date:  2009-10-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  915-21     Citation Subset:  IM    
Department of Rheumatology, Coimbra University Hospital, Praceta Prof. Mota Pinto, Coimbra 3000-075, Portugal.
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MeSH Terms
Antibodies, Antinuclear / blood*
Connective Tissue Diseases / blood*,  classification,  diagnosis
Cross-Sectional Studies
Disease Progression
Follow-Up Studies
Lupus Erythematosus, Systemic / blood
Middle Aged
Scleroderma, Systemic / blood
Severity of Illness Index*
Young Adult
Reg. No./Substance:
0/Antibodies, Antinuclear

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