Document Detail

Undetectable maternal serum unconjugated estriol levels in the second trimester: risk of perinatal complications associated with placental sulfatase deficiency.
MedLine Citation:
PMID:  9077601     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose was to determine the prevalence of undetectably low second-trimester maternal serum unconjugated estriol levels and the association with increased perinatal morbidity or mortality in pregnancies at risk for placental sulfatase deficiency. STUDY DESIGN: Nine centers in New England identified singleton pregnancies with undetectably low unconjugated estriol levels. Each unexplained case was matched with four controls; pregnancy outcome information was sought. RESULTS: Among 130,295 pregnancies surveyed, undetectably low unconjugated estriol levels were identified in 167 (13/10,000). Explanations included fetal death (53), overestimated gestational age (50), nonpregnancy (12), and chromosome abnormalities (5). The 41 unexplained cases were compared with 163 matched controls. Male offspring were more frequent (85%) among cases than among controls (55%). Although rates of perinatal complications were not significantly different, primary cesarean sections occurred about twice as often among cases. No perinatal deaths occurred. CONCLUSIONS: Neither severity of symptoms nor perinatal morbidity or mortality currently warrant routine interpretation of unexplained undetectably low unconjugated estriol levels as a marker for placental sulfatase deficiency.
L A Bradley; J A Canick; G E Palomaki; J E Haddow
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  176     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-04-10     Completed Date:  1997-04-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  531-5     Citation Subset:  AIM; IM    
Foundation for Blood Research, Scarborough, ME 04070-0190, USA.
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MeSH Terms
Case-Control Studies
Estriol / blood*
Obstetric Labor Complications / epidemiology*
Placenta / enzymology
Pregnancy Outcome*
Pregnancy Trimester, Second / blood*
Sex Ratio
Sulfatases / deficiency*
Grant Support
MCJ-2510033-09//PHS HHS
Reg. No./Substance:
50-27-1/Estriol; EC 3.1.6.-/Sulfatases

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