| Understanding the temporal codes of intra-cellular signals. | |
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MedLine Citation:
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PMID: 20956081 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The health of organisms and cells depends on appropriate responses to diverse internal and external cues, stimuli, or challenges, such as changes in hormone or cytokine levels, or exposure to a pathogen. Cellular responses must be tailored to the identity and intensity of the stimulus and therefore intra-cellular signals must carry information about both. However, signaling mediators often form intricate networks that react to multiple stimuli yet manage to produce stimulus-specific responses. The multi-functionality ('functional pleiotropism') of signaling nodes suggests that biological networks have evolved ways of passing physiologically relevant stimulus information through shared channels. Increasing evidence supports the notion that this is achieved in part through temporal regulation of signaling mediators' activities. The present challenge is to identify the features of temporal activity profile that represent information about a given stimulus and understand how cells read the temporal codes to control their responses. |
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Authors:
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Marcelo Behar; Alexander Hoffmann |
Publication Detail:
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Type: Journal Article; Review Date: 2010-10-16 |
Journal Detail:
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Title: Current opinion in genetics & development Volume: 20 ISSN: 1879-0380 ISO Abbreviation: Curr. Opin. Genet. Dev. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-16 Completed Date: 2011-01-31 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 9111375 Medline TA: Curr Opin Genet Dev Country: England |
Other Details:
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Languages: eng Pagination: 684-93 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Signaling Systems Laboratory, BioCircuits Institute, and San Diego Center for Systems Biology of Cellular Stress Responses, University of California, San Diego, 9500 Gillman Dr, La Jolla, CA 92093, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gene Expression Regulation Intracellular Space* Signal Transduction* |
| Grant Support | |
ID/Acronym/Agency:
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P01 GM071862-050005/GM/NIGMS NIH HHS; P50 GM085764-01A2/GM/NIGMS NIH HHS; R01 GM071573-05/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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