| Understanding the physiology and pharmacology of epidural and intrathecal opioids. | |
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MedLine Citation:
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PMID: 12516887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epidural and intrathecal opioid administration has become an important part of contemporary medical practice in a variety of clinical settings. It has been widely assumed that any opioid placed in the epidural or intrathecal spaces will produce highly selective spinally mediated analgesia that is superior to that produced by other analgesic techniques. Unfortunately, this is simply not true. In fact, multiple opioids are currently employed for spinal use despite the fact that clinical evidence has shown that spinal administration does not produce analgesia with a selective spinal mechanism or that the analgesia produced is not superior to that produced by intravenous administration. This chapter presents the basic science and clinical data available to assist clinicians in identifying which opioids are appropriate for spinal use and which are not. |
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Authors:
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Christopher M Bernards |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Best practice & research. Clinical anaesthesiology Volume: 16 ISSN: 1521-6896 ISO Abbreviation: Best Pract Res Clin Anaesthesiol Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2003-01-08 Completed Date: 2003-04-22 Revised Date: 2011-04-28 |
Medline Journal Info:
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Nlm Unique ID: 101121446 Medline TA: Best Pract Res Clin Anaesthesiol Country: England |
Other Details:
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Languages: eng Pagination: 489-505 Citation Subset: IM |
Affiliation:
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University of Washington, Box 356540, Seattle, WA 98195, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesia, Epidural* Analgesics, Opioid / pharmacokinetics*, pharmacology* Cerebrospinal Fluid / metabolism Epidural Space / metabolism Humans Injections, Spinal Meninges / metabolism Spinal Cord / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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