Document Detail

Understanding opioid tolerance in cancer pain.
MedLine Citation:
PMID:  11759304     Owner:  NLM     Status:  MEDLINE    
PURPOSE/OBJECTIVES: To review opioid tolerance in chronic cancer pain, define the phenomenon and its scope, review physiologic mechanisms, and discuss clinical strategies to identify and manage this complex issue. DATA SOURCES: Review articles, case studies, original research, and published guidelines. DATA SYNTHESIS: Novel therapies to prevent/reverse tolerance are being investigated with a possible future role for N-methyl-d-aspartate antagonists. CONCLUSIONS: Greater nursing research is needed to identify patient risk factors for tolerance development and clinical measurement of the phenomenon. Understanding cellular mechanisms for tolerance may contribute to better management. IMPLICATIONS FOR NURSING PRACTICE: Nursing knowledge of tolerance is important to provide the basis for accurate patient assessment, education, and pain management.
J Cady
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Oncology nursing forum     Volume:  28     ISSN:  0190-535X     ISO Abbreviation:  Oncol Nurs Forum     Publication Date:    2001 Nov-Dec
Date Detail:
Created Date:  2001-12-10     Completed Date:  2002-04-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7809033     Medline TA:  Oncol Nurs Forum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1561-8; quiz 1569-70     Citation Subset:  IM; N    
Department of Anesthesiology, Virginia Mason Medical Center, Seattle, WA, USA.
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MeSH Terms
Analgesics, Opioid / pharmacology*
Chronic Disease
Drug Tolerance* / physiology
N-Methylaspartate / antagonists & inhibitors
Neoplasms / complications*
Nursing Assessment
Oncologic Nursing / methods
Pain / drug therapy*,  etiology*,  nursing,  physiopathology
Pain Measurement
Patient Education as Topic
Receptors, Opioid / drug effects,  physiology
Risk Factors
Reg. No./Substance:
0/Analgesics, Opioid; 0/Receptors, Opioid; 6384-92-5/N-Methylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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