Document Detail

Understanding the nutrigenomic definitions and concepts at the food-genome junction.
MedLine Citation:
PMID:  18687041     Owner:  NLM     Status:  MEDLINE    
The marked differences in individual response to dietary factors have led to major controversies in nutrition and puzzled nutrition scientists over the last century. The emerging field of nutrigenomics helps us to understand the basis for some of these differences and also promises us the ability to tailor diet based on individual genetic makeup. Great advances in Human Genome Project, documentation of single nucleotide polymorphisms (SNPs) in candidate genes and their association with metabolic imbalances have gradually added new tests to the nutrigenomic panel. Studies based on ethnopharmacology and phytotherapy concepts showed that nutrients and botanicals can interact with the genome causing marked changes in gene expression. This has led to the commercial development of nutraceuticals and functional foods that can modify negative health effects of individual genetic profile bringing the field to the "food/genome" junction. Despite the promise of nutrigenomics to personalize diet, there is skepticism whether it can truly bring about meaningful modification of the risk factors connected to chronic diseases, due to the lack of large scale nutrition intervention studies. Several intervention studies currently underway in the United States and abroad (Israel, Spain, and France) will further help validate nutrigenomic concepts. France has already introduced a National Nutrition and Health Program to assess nutritional status and risk of major metabolic diseases. As the field(s) related to nutritional genomics advance in their scope, it is essential that: (a) strict guidelines be followed in the nomenclature and definition of the subdisciplines; and (b) the state/federal regulatory guidelines be updated for diagnostic laboratories, especially for those offering tests directly to the public (without a physician's request) to help protect the consumer.
M T Ravi Subbiah
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Omics : a journal of integrative biology     Volume:  12     ISSN:  1557-8100     ISO Abbreviation:  OMICS     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-01     Completed Date:  2009-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101131135     Medline TA:  OMICS     Country:  United States    
Other Details:
Languages:  eng     Pagination:  229-35     Citation Subset:  IM    
Department of Internal Medicine, University of Cincinnati Medical Center Cincinnati, Ohio 45267, USA.
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MeSH Terms
Dietary Supplements
Genome, Human*
Metabolic Diseases / diet therapy,  genetics,  prevention & control
Nutrigenomics / education,  trends*
Nutritional Physiological Phenomena / genetics*
Preventive Medicine / education,  trends
Terminology as Topic*

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