Document Detail


Understanding multimodal biological decisions from single cell and population dynamics.
MedLine Citation:
PMID:  22585551     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Modern techniques on single-cell and -molecule resolution reveal that gene and protein expressions between cells of an otherwise identical group are stochastic in time, and clonal population of cells display heterogeneity in the abundance of a given protein per cell at any measured time. Today, combinatorially, stochasticity and heterogeneity are considered as biological noise and are essential for generating phenotypic variations, cell fate decisions and amplification of molecular signals. Here, several works from experimental and theoretical aspects that show multimodal biological decisions at single cell and population level are reviewed. The emerging lessons from these studies suggest that, for yielding multimodal decisions, living systems are guided by well-defined nonlinear deterministic processes which are sensitive to specific range of biological parameters. WIREs Syst Biol Med 2012 doi: 10.1002/wsbm.1175 For further resources related to this article, please visit the WIREs website.
Authors:
Kumar Selvarajoo
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-14
Journal Detail:
Title:  Wiley interdisciplinary reviews. Systems biology and medicine     Volume:  -     ISSN:  1939-005X     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101516550     Medline TA:  Wiley Interdiscip Rev Syst Biol Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan. kumar@ttck.keio.ac.jp.
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