| Understanding the mechanism of adrenocortical steroid hypertension. | |
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MedLine Citation:
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PMID: 2536448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies of the mechanism of ACTH induced hypertension in sheep have led to the hypothesis that adrenocortical steroids may raise blood pressure by a "hypertensinogenic" action which can be distinguished from effects mediated by occupancy of classical mineralocorticoid or glucocorticoid receptors. This concept is supported by recent structure-activity studies using synthetic and naturally occurring steroids. Development of steroid hypertension is rapid (4-6 h) and although associated with an increase in cardiac output, changes in total peripheral resistance are important. Many different mechanisms have been proposed to explain how steroids raise blood pressure. In sheep it has been shown that the autonomic nervous system and vasoactive prostanoids appear to buffer, rather than cause, the rise in blood pressure. The renin-angiotensin system, AVP and serotonin are also unlikely to be involved. Further, the effects of steroids on blood pressure are not simply related to effects on Na status and changes in body fluid volumes. A direct involvement of the central nervous system remains to be established. In understanding how ACTH raises blood pressure, studies in sheep have shown that it is important to try and dissociate the effects of steroids involved in development of hypertension from the many other actions of steroids. |
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Authors:
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B A Scoggins; J P Coghlan; D A Denton; A F Reid; C D Spence; J A Whitworth |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of steroid biochemistry Volume: 32 ISSN: 0022-4731 ISO Abbreviation: J. Steroid Biochem. Publication Date: 1989 Jan |
Date Detail:
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Created Date: 1989-03-09 Completed Date: 1989-03-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0260125 Medline TA: J Steroid Biochem Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 205-8 Citation Subset: IM |
Affiliation:
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Howard Florey Institute of Experimental Physiology and Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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physiology* Adrenocorticotropic Hormone / pharmacology Animals Blood Pressure / drug effects Humans Hypertension / etiology, physiopathology* Models, Biological |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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