| Understanding hippocampal sclerosis in the elderly: epidemiology, characterization, and diagnostic issues. | |
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MedLine Citation:
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PMID: 18713571 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hippocampal sclerosis (HS) is a pathologic term used to describe severe loss of neurons and reactive gliosis without cystic cavitation in the CA1 sector of the hippocampus. In late life, HS is associated with hippocampal atrophy, severe amnesia, and slowly progressive dementia without clinical seizure activity. HS is difficult to distinguish clinically from Alzheimer's disease and is often diagnosed postmortem. In autopsy series, HS may be found without significant other pathology (2%-4% of cases), but it occurs frequently in combination with other vascular and neurodegenerative disorders (12%-20% of cases). HS is found bilaterally in 50% of cases and unilaterally in 50% of cases, with similar predilection for the right versus left hemisphere. The pathogenesis of HS is unknown and may be multifactorial in origin, possibly due to anoxic/ischemic injury or TDP-43-related neurodegeneration. Little is known about the prevention and treatment of late-life HS, although circumstantial evidence suggests the importance of identifying and treating vascular risk factors. |
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Authors:
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Chris Zarow; Traci E Sitzer; Helena C Chui |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current neurology and neuroscience reports Volume: 8 ISSN: 1534-6293 ISO Abbreviation: Curr Neurol Neurosci Rep Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-20 Completed Date: 2008-10-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100931790 Medline TA: Curr Neurol Neurosci Rep Country: United States |
Other Details:
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Languages: eng Pagination: 363-70 Citation Subset: IM |
Affiliation:
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University of Southern California, Rancho Los Amigos National Rehabilitation Center, 7601 E. Imperial Highway, Medical Science Building, Room 26, Downey, CA 90242, USA. zarow@usc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / diagnosis Amnesia, Anterograde / etiology Atrophy Cerebrovascular Disorders / complications Comorbidity DNA-Binding Proteins / analysis Dementia / etiology Diagnosis, Differential Disease Progression Female Gliosis / etiology Hippocampus / pathology* Humans Hypoxia-Ischemia, Brain / complications Male Neurodegenerative Diseases / diagnosis, epidemiology, pathology*, psychology Prevalence Risk Factors Sclerosis tau Proteins / analysis |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/MAPT protein, human; 0/protein TDP-43; 0/tau Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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