Document Detail

Understanding hippocampal sclerosis in the elderly: epidemiology, characterization, and diagnostic issues.
MedLine Citation:
PMID:  18713571     Owner:  NLM     Status:  MEDLINE    
Hippocampal sclerosis (HS) is a pathologic term used to describe severe loss of neurons and reactive gliosis without cystic cavitation in the CA1 sector of the hippocampus. In late life, HS is associated with hippocampal atrophy, severe amnesia, and slowly progressive dementia without clinical seizure activity. HS is difficult to distinguish clinically from Alzheimer's disease and is often diagnosed postmortem. In autopsy series, HS may be found without significant other pathology (2%-4% of cases), but it occurs frequently in combination with other vascular and neurodegenerative disorders (12%-20% of cases). HS is found bilaterally in 50% of cases and unilaterally in 50% of cases, with similar predilection for the right versus left hemisphere. The pathogenesis of HS is unknown and may be multifactorial in origin, possibly due to anoxic/ischemic injury or TDP-43-related neurodegeneration. Little is known about the prevention and treatment of late-life HS, although circumstantial evidence suggests the importance of identifying and treating vascular risk factors.
Chris Zarow; Traci E Sitzer; Helena C Chui
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current neurology and neuroscience reports     Volume:  8     ISSN:  1534-6293     ISO Abbreviation:  Curr Neurol Neurosci Rep     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-20     Completed Date:  2008-10-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100931790     Medline TA:  Curr Neurol Neurosci Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  363-70     Citation Subset:  IM    
University of Southern California, Rancho Los Amigos National Rehabilitation Center, 7601 E. Imperial Highway, Medical Science Building, Room 26, Downey, CA 90242, USA.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / diagnosis
Amnesia, Anterograde / etiology
Cerebrovascular Disorders / complications
DNA-Binding Proteins / analysis
Dementia / etiology
Diagnosis, Differential
Disease Progression
Gliosis / etiology
Hippocampus / pathology*
Hypoxia-Ischemia, Brain / complications
Neurodegenerative Diseases / diagnosis,  epidemiology,  pathology*,  psychology
Risk Factors
tau Proteins / analysis
Reg. No./Substance:
0/DNA-Binding Proteins; 0/MAPT protein, human; 0/protein TDP-43; 0/tau Proteins

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