Document Detail

Understanding the genetics of coronary artery disease through the lens of noninvasive imaging.
MedLine Citation:
PMID:  22149524     Owner:  NLM     Status:  MEDLINE    
Coronary artery disease is a common condition with a known heritable component that has spurred interest in genetic research for decades, resulting in a handful of candidate genes and an appreciation for the complexity of its genetic contributions. Recent advances in sequencing technologies have resulted in large-scale association studies, possibly adding to our current understanding of the genetics of coronary artery disease. Sifting through the statistical noise, however, requires the selection of effective phenotypic markers. New imaging technologies have improved our ability to detect subclinical atherosclerosis in a safe and reproducible manner in large numbers of patients. In this article, we propose that advances in imaging technology have generated improved phenotypic markers for genetic association studies of coronary artery disease.
Eunice Yang; Jose D Vargas; David A Bluemke
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Expert review of cardiovascular therapy     Volume:  10     ISSN:  1744-8344     ISO Abbreviation:  Expert Rev Cardiovasc Ther     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-13     Completed Date:  2012-04-23     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101182328     Medline TA:  Expert Rev Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  27-36     Citation Subset:  IM    
Johns Hopkins School of Medicine, Baltimore, MD, USA.
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MeSH Terms
Atherosclerosis / diagnosis,  pathology
Biological Markers
Calcinosis / diagnosis,  pathology
Carotid Intima-Media Thickness
Coronary Angiography / adverse effects,  methods*
Coronary Artery Disease / diagnosis*,  genetics,  pathology
Early Diagnosis
Genetic Association Studies / methods*
Magnetic Resonance Angiography / adverse effects,  methods*
Multidetector Computed Tomography
Plaque, Atherosclerotic / diagnosis*,  pathology
Positron-Emission Tomography and Computed Tomography
Grant Support
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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