| Understanding the genetics of coronary artery disease through the lens of noninvasive imaging. | |
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MedLine Citation:
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PMID: 22149524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coronary artery disease is a common condition with a known heritable component that has spurred interest in genetic research for decades, resulting in a handful of candidate genes and an appreciation for the complexity of its genetic contributions. Recent advances in sequencing technologies have resulted in large-scale association studies, possibly adding to our current understanding of the genetics of coronary artery disease. Sifting through the statistical noise, however, requires the selection of effective phenotypic markers. New imaging technologies have improved our ability to detect subclinical atherosclerosis in a safe and reproducible manner in large numbers of patients. In this article, we propose that advances in imaging technology have generated improved phenotypic markers for genetic association studies of coronary artery disease. |
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Authors:
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Eunice Yang; Jose D Vargas; David A Bluemke |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Expert review of cardiovascular therapy Volume: 10 ISSN: 1744-8344 ISO Abbreviation: Expert Rev Cardiovasc Ther Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-13 Completed Date: 2012-04-23 Revised Date: 2013-05-22 |
Medline Journal Info:
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Nlm Unique ID: 101182328 Medline TA: Expert Rev Cardiovasc Ther Country: England |
Other Details:
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Languages: eng Pagination: 27-36 Citation Subset: IM |
Affiliation:
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Johns Hopkins School of Medicine, Baltimore, MD, USA. bluemked@nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Atherosclerosis
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diagnosis,
pathology Biological Markers Calcinosis / diagnosis, pathology Carotid Intima-Media Thickness Coronary Angiography / adverse effects, methods* Coronary Artery Disease / diagnosis*, genetics, pathology Early Diagnosis Genetic Association Studies / methods* Humans Magnetic Resonance Angiography / adverse effects, methods* Multidetector Computed Tomography Phenotype Plaque, Atherosclerotic / diagnosis*, pathology Positron-Emission Tomography and Computed Tomography |
| Grant Support | |
ID/Acronym/Agency:
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ZIA CL090019-02/CL/CLC NIH HHS; ZIA EB000072-03/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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