| Understanding fragile X syndrome: insights from retarded flies. | |
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MedLine Citation:
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PMID: 12086633 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fragile X syndrome, the most common form of inherited mental retardation, is caused by loss-of-function mutations in the fragile X mental retardation 1 (fmr1) gene. FMR1 is an RNA binding protein that is highly expressed in neurons of the central nervous system. Recent studies in Drosophila indicate that FMR1 plays an important role in synaptogenesis and axonal arborization, which may underlie the observed deficits in flight ability and circadian behavior of fmr1 mutant flies. The relevance of these studies to our understanding of fragile X syndrome is discussed. |
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Authors:
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Fen-Biao Gao |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Neuron Volume: 34 ISSN: 0896-6273 ISO Abbreviation: Neuron Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-06-27 Completed Date: 2002-07-22 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: United States |
Other Details:
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Languages: eng Pagination: 859-62 Citation Subset: IM |
Affiliation:
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Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, CA 94141, USA. fgao@gladstone.ucsf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Drosophila / chemistry, genetics Drosophila Proteins / deficiency, genetics* Fragile X Mental Retardation Protein Fragile X Syndrome / genetics*, metabolism Mental Retardation / genetics*, metabolism Nerve Tissue Proteins / biosynthesis, genetics RNA-Binding Proteins* Sequence Homology |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; 0/Nerve Tissue Proteins; 0/RNA-Binding Proteins; 139135-51-6/Fragile X Mental Retardation Protein |
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