Document Detail

Understanding endometrial physiology and menstrual disorders in the 1990s.
MedLine Citation:
PMID:  8329654     Owner:  NLM     Status:  MEDLINE    
Two byproducts of in vitro fertilization, transvaginal ultrasonography and hormonal preparation of endometrial receptivity for oocyte donation, have been the source of great progress in endometrial physiology. In practical terms, transvaginal ultrasonography has permitted the assessment of endometrial thickness and more precise echogenicity, the latter being a potential reflector of the secretory changes induced by progesterone. Pulsed and color Doppler ultrasonography have further enhanced the diagnostic performance of transvaginal ultrasonography so that the vascular tone of uterine arteries can be correlated with the hormonal effects on the endometrium and the degree of endometrial receptivity. Because of the excellent pregnancy rates achieved with oocyte donation, estradiol and progesterone replacement regimens have become true experimental models for studying endometrial physiology and physiopathology. Although even extreme alterations in the estradiol-to-progesterone ratio appear to have little effect on endometrial morphology, recent studies suggest an extreme sensitivity of the endometrium to progesterone, particularly early in the luteal phase. The physiology of uterine bleeding and its disorders have been reconsidered in the light of these new findings. In the menstrual cycle, uterine bleeding is triggered by dropping progesterone levels, regardless of estradiol levels.
D de Ziegler; P Bouchard
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in obstetrics & gynecology     Volume:  5     ISSN:  1040-872X     ISO Abbreviation:  Curr. Opin. Obstet. Gynecol.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-08-19     Completed Date:  1993-08-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9007264     Medline TA:  Curr Opin Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  378-88     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Hôpital A. Béclère, Clamart, France.
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MeSH Terms
Endometrium / blood supply,  drug effects,  physiology*,  ultrasonography
Estrogens / physiology
Menstruation Disturbances / physiopathology*,  ultrasonography
Oocytes / transplantation*
Ovulation Induction
Progesterone / physiology
Uterus / blood supply
Vascular Resistance
Reg. No./Substance:
0/Estrogens; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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