Document Detail

Understanding cytokines. Part I: Physiology and mechanism of action.
MedLine Citation:
PMID:  11232509     Owner:  NLM     Status:  MEDLINE    
This is the first of a 2-part article on understanding cytokines. Cytokines are intercellular signaling proteins released from virtually all nucleated cells that influence growth and cellular proliferation in a wide range of tissues. Cytokines have immune modulating effects and are understood to control most of the physical and psychological symptoms associated with infection and inflammation. Cytokines also influence reproduction and bone remodeling. Dysregulation of the cytokine cellular system has significant implications in the development of a variety of illnesses, including most autoimmune disorders, many diseases of the cardiovascular system, osteoporosis, asthma, and depression. For nurses to be adequately informed when caring for clients with chronic illnesses and to be sufficiently knowledgeable when evaluating client outcomes, an understanding of the physiology of cytokines, the occurrences of dysregulation, and the role of cytokines in health and illness is essential. In Part I of this review, cytokine physiology is presented, with an emphasis on characteristics, categories, and mechanism of action. Specific instances of cytokine function in health and disease and implications for nursing research and practice are presented in Part II.
E J Corwin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biological research for nursing     Volume:  2     ISSN:  1099-8004     ISO Abbreviation:  Biol Res Nurs     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2001-03-05     Completed Date:  2001-03-22     Revised Date:  2006-10-13    
Medline Journal Info:
Nlm Unique ID:  9815758     Medline TA:  Biol Res Nurs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  30-40     Citation Subset:  IM; N    
School of Nursing and Intercollege Physiology Program, Pennsylvania State University, 307C Health and Human Development East, University Park, PA 16802, USA.
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MeSH Terms
Bone Remodeling / physiology
Cell Division / physiology
Cytokines / analysis,  classification,  immunology*,  isolation & purification,  physiology*
Growth / physiology
Infection / immunology
Inflammation / immunology
Leukocytes / immunology
Reproduction / physiology
Signal Transduction / physiology
Reg. No./Substance:

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