Document Detail

Understanding coronary artery disease using twin studies.
MedLine Citation:
PMID:  23142714     Owner:  NLM     Status:  Publisher    
Twins have fascinated human communities since the beginning of recorded history. In cardiovascular research, twin studies played a pivotal role in the discovery of the genetic basis of coronary artery disease, myocardial infarction and most of their associated risk factors. Matched for age, prenatal and postnatal environmental factors, discordant monozygous twin pairs provide a means to enhance the power to analyse epigenetic and metagenomic mechanisms. In the near future, combining the monozygous discordant twin study design with the recent advance of the sequencing technologies it will be possible to explore the complexity of the gene-environment relationships and individual variability to provide important insights into the pathogenesis of coronary artery disease/myocardial infarction.
Massimo Mangino; Tim Spector
Related Documents :
11206014 - Calming the plaque to delay intervention for 24 hours in acute coronary syndromes.
2182244 - Aspirin in chronic cardiovascular disease and acute myocardial infarction.
18001624 - Clopidogrel and risk for acute coronary events.
25420394 - Amyloidosis of the aortic root in a patient with polyarteritis nodosa.
12943874 - Relations among heart failure severity, left ventricular loading conditions, and repola...
1548904 - Surgical treatment of ventricular tachycardia by balloon electric shock ablation. poten...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-10
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  -     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
King's College London, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Magnetic drug targeting in a permeable microvessel.
Next Document:  Effects of valence and arousal on written word recognition: Time course and ERP correlates.