| Understanding the consequences of contrast-induced nephropathy. | |
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MedLine Citation:
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PMID: 14668705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several investigations have discovered important physiologic links in the development of contrast-induced nephropathy (CIN). Studies using a canine kidney model showed that contrast media produce a direct cytotoxic effect on the renal structures. Also, there is increasing evidence that apoptosis is involved in CIN as a result of cell injury. It has been suggested that hemodynamic changes resulting from administration of contrast media may contribute to the development of CIN, although the data are not conclusive. Several vasoactive substances, such as endothelin, prostaglandins, nitric oxide, and adenosine, have been implicated in the pathogenesis of CIN, as have immune mechanisms. Several factors contribute to the development of CIN, including preexisting renal insufficiency, older age, diabetes mellitus, reduced left ventricular systolic function, advanced heart failure, acute myocardial infarction, and shock. The authors also present the risk score they developed to help clinicians identify patients with different responses to contrast exposure. |
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Authors:
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Eugenia Nikolsky; Roxana Mehran |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Reviews in cardiovascular medicine Volume: 4 Suppl 5 ISSN: 1530-6550 ISO Abbreviation: Rev Cardiovasc Med Publication Date: 2003 |
Date Detail:
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Created Date: 2003-12-11 Completed Date: 2004-02-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100960007 Medline TA: Rev Cardiovasc Med Country: United States |
Other Details:
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Languages: eng Pagination: S10-8 Citation Subset: IM |
Affiliation:
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Cardiovascular Research Foundation, Lenox Hill Heart and Vascular Institute, New York, New York, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Clinical Trials as Topic Contrast Media / adverse effects* Hemodynamics Humans Kidney Diseases / epidemiology, etiology*, physiopathology* Models, Animal Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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