Document Detail

Understanding the cell biology of antigen presentation: the dendritic cell contribution.
MedLine Citation:
PMID:  12892788     Owner:  NLM     Status:  MEDLINE    
The study of the cell biology of antigen processing and presentation has greatly contributed to our understanding of the immune response. The work of many immunologically inclined cell biologists has also permitted us to gain new insights on cellular mechanisms shared by many cell types. Dendritic cells are master regulators of the immune system and consequently have received a lot of attention in recent years. With the aim of controlling antigen processing and presentation, the solutions used by dendritic cells to respond to environmental changes are numerous and surprising. In the presence of pathogens, dendritic cells regulate strongly their endocytic pathway by interfering with uptake, proteolysis, membrane dynamics and transport in and out of the lysosome to become the most potent antigen-presenting cells known.
Evelina Gatti; Philippe Pierre
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in cell biology     Volume:  15     ISSN:  0955-0674     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-01     Completed Date:  2004-03-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  468-73     Citation Subset:  IM    
Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Université de la Méditerranée, Campus de Luminy, Case 906, 13288, Cedex 09, Marseille, France.
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MeSH Terms
Antigen Presentation / immunology*
Antigens / metabolism*
Dendritic Cells / immunology*
Endocytosis / immunology*
Endosomes / immunology
Histocompatibility Antigens Class II / immunology
Lysosomes / immunology,  metabolism
Protein Transport / immunology
Reg. No./Substance:
0/Antigens; 0/Histocompatibility Antigens Class II

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