| Understanding the cell behavior on nano-/micro-patterned surfaces. | |
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MedLine Citation:
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PMID: 22812706 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: This article reports on studies conducted in the same laboratory on interactions between patterned substrates with different pattern dimensions and chemistries, and various types of cells. Materials & methods: In order to compare the influence of various parameters, bone marrow stromal cells, retinal pigment epithelial cells, human corneal stromal cells (keratocytes), Saos-2 (human osteosarcoma cells), human microvascular endothelial cells and vascular smooth muscle cells were tested on surfaces with different physical patterns and chemical properties. Results: It was observed that cell type and surface topography are more influential than surface chemistry in determining the alignment tendency of a cell on a substrate surface. Low walls (several microns high) could not confine cells into the microgrooves of the films but alignment was still possible if the cells had a natural alignment property. Conclusion: This information is very useful in designing tissue engineering scaffolds and in the long-term success of implants. Original submitted 30 November 2010; Revised submitted 4 January 2012. |
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Authors:
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Vasif Hasirci; Brian J Pepe-Mooney |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-20 |
Journal Detail:
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Title: Nanomedicine (London, England) Volume: - ISSN: 1748-6963 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101278111 Medline TA: Nanomedicine (Lond) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Middle East Technical University, Biotechnology Research Unit, Ankara 06531, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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