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Understanding brain function through small vessel disease: What zebras can teach us about horses.
MedLine Citation:
PMID:  24793189     Owner:  NLM     Status:  Publisher    
So goes the adage attributed to Dr. Theodore Woodward of the University of Maryland. But perhaps considering the habits of zebras could teach us about their more common equine cousins. Traditionally, our knowledge about the correlation of normal structure and function in the brain has relied, to a large extent, on studying the disruption wrought by disease processes on normal function, whether this disrupted structure was detected at autopsy or more recently by CT and MRI. This led to the common dictum that neurology was learned "stroke by stroke" (lesion-symptom mapping). In the last 5 years, higher-resolution MRI scanners (3T and 7T machines) and innovative scanning protocols and analytic methods have exponentially expanded our ability to "see" subtle details of brain structure in living persons.(1) In parallel, genetic studies have shown that mildly damaging genetic variants located within genes associated with severe monogenic disorders ("the diagnostic zebras") may explain a larger proportion of common disease ("the horses") than had been previously suspected. One example is NOTCH3, the gene underlying cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), variants within which are associated with greater white matter lesion load in healthy adults in the community.(2.)
Sudha Seshadri; Frank-Erik de Leeuw
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-2
Journal Detail:
Title:  Neurology     Volume:  -     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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