Document Detail

Understanding neonatal jaundice: a perspective on causation.
MedLine Citation:
PMID:  20675237     Owner:  NLM     Status:  MEDLINE    
Neonatal jaundice can be best understood as a balance between the production and elimination of bilirubin, with a multitude of factors and conditions affecting each of these processes. When an imbalance results because of an increase in circulating bilirubin (or the bilirubin load) to significantly high levels (severe hyperbilirubinemia), it may cause permanent neurologic sequelae (kernicterus). In most infants, an increase in bilirubin production (e.g., due to hemolysis) is the primary cause of severe hyperbilirubinemia, and thus reducing bilirubin production is a rational approach for its management. The situation can become critical in infants with an associated impaired bilirubin elimination mechanism as a result of a genetic deficiency and/or polymorphism. Combining information about bilirubin production and genetic information about bilirubin elimination with the tracking of bilirubin levels means that a relative assessment of jaundice risk might be feasible. Information on the level of bilirubin production and its rate of elimination may help to guide the clinical management of neonatal jaundice.
Ronald S Cohen; Ronald J Wong; David K Stevenson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Pediatrics and neonatology     Volume:  51     ISSN:  1875-9572     ISO Abbreviation:  Pediatr Neonatol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-08-02     Completed Date:  2010-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101484755     Medline TA:  Pediatr Neonatol     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  143-8     Citation Subset:  IM    
Copyright Information:
2010 Taiwan Pediatric Association. Published by Elsevier B.V. All rights reserved.
Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA.
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MeSH Terms
Bilirubin / metabolism*
Carbon Monoxide / toxicity
Diagnosis, Differential
Infant, Newborn
Jaundice, Neonatal / diagnosis,  etiology*,  physiopathology*
Grant Support
Reg. No./Substance:
630-08-0/Carbon Monoxide; 635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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