Document Detail


Understanding how data triangulation identifies acute toxicity of novel psychoactive drugs.
MedLine Citation:
PMID:  22581465     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over the last decade, there has been an increase in the availability and use of novel psychoactive substances (also known as "legal highs"). There is limited information available on the potential acute toxicity (harms) associated with the use of these novel psychoactive substances. Gold standard evidence, such as animal studies or human clinical trials, is rarely available to users or healthcare professionals. However, it is possible to use triangulation of data on the acute toxicity from multiple sources to describe the overall pattern of toxicity associated with a novel psychoactive substance. In this review, we will describe these potential data sources, which include self-reported toxicity on internet discussion fora, data from sub-population user surveys, data from regional and national poisons information services and published case reports and case series. We will then describe how pattern of acute toxicity associated with the use of the cathinone mephedrone (4-methylmethcathinone) was established using triangulation of these different data sources.
Authors:
D M Wood; P I Dargan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of medical toxicology : official journal of the American College of Medical Toxicology     Volume:  8     ISSN:  1937-6995     ISO Abbreviation:  J Med Toxicol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-20     Completed Date:  2013-02-12     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  101284598     Medline TA:  J Med Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  300-3     Citation Subset:  IM    
Affiliation:
Clinical Toxicology Service, Guy's and St Thomas' NHS Foundation Trust and King's Health Partners, London, UK. David.Wood@gstt.nhs.uk
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MeSH Terms
Descriptor/Qualifier:
Alkaloids / toxicity*
Animals
Databases, Factual
Humans
Internet
Methamphetamine / analogs & derivatives*,  toxicity
Psychotropic Drugs / toxicity*
Street Drugs / toxicity*
Toxicity Tests, Acute
Chemical
Reg. No./Substance:
0/Alkaloids; 0/Psychotropic Drugs; 0/Street Drugs; 537-46-2/Methamphetamine; 540EI4406J/cathinone; 8BA8T27317/mephedrone
Comments/Corrections

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