Document Detail


Understanding Guyton's venous return curves.
MedLine Citation:
PMID:  21666119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Based on observations that as cardiac output (as determined by an artificial pump) was experimentally increased the right atrial pressure decreased, Arthur Guyton and coworkers proposed an interpretation that right atrial pressure represents a back pressure restricting venous return (equal to cardiac output in steady state). The idea that right atrial pressure is a back pressure limiting cardiac output and the associated idea that "venous recoil" does work to produce flow have confused physiologists and clinicians for decades because Guyton's interpretation interchanges independent and dependent variables. Here Guyton's model and data are reanalyzed to clarify the role of arterial and right atrial pressures and cardiac output and to clearly delineate that cardiac output is the independent (causal) variable in the experiments. Guyton's original mathematical model is used with his data to show that a simultaneous increase in arterial pressure and decrease in right atrial pressure with increasing cardiac output is due to a blood volume shift into the systemic arterial circulation from the systemic venous circulation. This is because Guyton's model assumes a constant blood volume in the systemic circulation. The increase in right atrial pressure observed when cardiac output decreases in a closed circulation with constant resistance and capacitance is due to the redistribution of blood volume and not because right atrial pressure limits venous return. Because Guyton's venous return curves have generated much confusion and little clarity, we suggest that the concept and previous interpretations of venous return be removed from educational materials.
Authors:
Daniel A Beard; Eric O Feigl
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-06-10
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  301     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-31     Completed Date:  2011-11-01     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H629-33     Citation Subset:  IM    
Affiliation:
Department of Physiology, Biotechnology and Bioengineering Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA. dbeard@mcw.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Atrial Function, Right
Blood Circulation*
Blood Pressure
Blood Volume
Cardiac Output
Hemodynamics*
Humans
Models, Cardiovascular*
Reproducibility of Results
Vascular Capacitance
Vascular Resistance
Veins / physiology*
Grant Support
ID/Acronym/Agency:
HL-072011/HL/NHLBI NIH HHS; HL-82781/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
Am J Physiol Heart Circ Physiol. 2013 Feb 1;304(3):H489   [PMID:  23377151 ]
Am J Physiol Heart Circ Physiol. 2013 Feb 1;304(3):H487-8   [PMID:  23377150 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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