| Understanding brain injury and neurodevelopmental disabilities in the preterm infant: the evolving role of advanced magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 20109973 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The high incidence of neurodevelopmental disability in premature infants requires continued efforts at understanding the underlying microstructural changes in the brain that cause this perturbation in normal development. Magnetic resonance imaging (MRI) methods offer great potential to fulfill this need. Serial MR imaging and the application of newer analysis techniques, such as diffusion tensor imaging (DTI), volumetric MR analysis, cortical surface analysis, functional connectivity MRI (fcMRI) and diffusion tractography, provide important insights into the trajectory of brain development in the premature infant and the impact of injury on this developmental trajectory. While some of these imaging techniques are currently available in the research setting only, other measures, such as DTI and brain metric measures can be used clinically. MR imaging also has an enormous potential to be used as a surrogate, short-term outcome measure in clinical studies evaluating new therapeutic interventions of neuroprotection of the developing brain. In this article, we review the current status of these advanced MR imaging techniques. |
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Authors:
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Amit M Mathur; Jeffrey J Neil; Terrie E Inder |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in perinatology Volume: 34 ISSN: 1558-075X ISO Abbreviation: Semin. Perinatol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-29 Completed Date: 2010-04-22 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 7801132 Medline TA: Semin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 57-66 Citation Subset: IM |
Copyright Information:
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(c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Newborn Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA. mathur_a@wustl.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain Damage, Chronic
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diagnosis,
pathology* Diffusion Magnetic Resonance Imaging / methods* Diffusion Tensor Imaging / methods* Humans Infant, Newborn Infant, Premature Magnetic Resonance Imaging / methods* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HD057098-01/HD/NICHD NIH HHS; R01 HD057098-02S1/HD/NICHD NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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