Document Detail

Underlying diseases and co-factors in patients with severe chronic pruritus: a 3-year retrospective study.
MedLine Citation:
PMID:  17989889     Owner:  NLM     Status:  MEDLINE    
Chronic pruritus is a symptom of many diseases, with studies pending investigating its prevalence or incidence. The aim of this study was to describe the characteristics of the underlying diseases in a large number of patients. A total of 263 patients (110 men, 153 women; age range 8-95 years; mean 55.9 years) were included in the study. The following data were collected from patients presenting over a 3-year period: gender, age, history, skin lesions, laboratory, histological and radiological investigations. An underlying dermatosis was identified in 41.8% of patients, a systemic disease including unidentified neoplasms in 13.3% and a neurological disorder in 0.4%. No disease was found in 44.5% of patients. Among the patients in whom no disease was found, 55.6% of the, mainly elderly, patients had an accumulation of many co-factors, suggesting an own subgroup with multifactorial origin for the pruritus. The distribution and type of secondary scratch lesions gave no clue as to the underlying disease. In conclusion, patients with chronic pruritus present a inhomgeneous collective with different underlying diseases, including malignancy, necessitating thorough investigation.
Franz Sommer; Peter Hensen; Barbara Böckenholt; Dieter Metze; Thomas A Luger; Sonja Ständer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  87     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-08     Completed Date:  2008-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  510-6     Citation Subset:  IM    
Clinical Neurodermatology, Department of Dermatology, University of Münster, Germany.
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MeSH Terms
Aged, 80 and over
Candidiasis / complications
Chronic Disease
Drug Therapy / adverse effects
Endocrine System Diseases / complications
Hematologic Diseases / complications
Middle Aged
Neoplasms / complications
Pruritus / etiology*,  pathology
Retrospective Studies
Skin Diseases / complications
Statistics, Nonparametric

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