Document Detail


Underlying cardiomyopathy in patients with ST-segment elevation in the right precordial leads.
MedLine Citation:
PMID:  16723793     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Ventricular fibrillation (VF) and sudden death (SD) may occur in patients with ST-segment elevation in the right precordial leads. The mechanism of such events is unclear, so the aim of the present study was to assess whether there is an underlying morphological or pathological abnormality in these patients. METHODS AND RESULTS: Fourteen consecutive patients (44+/-10 years old, all male) with ST-segment elevation of more than 2 mm in the right precordial leads underwent a cardiac evaluation, including right ventriculography and endomyocardial biopsy. The ST-segment changes after the administration of sodium-channel blockers were also evaluated. Two patients survived documented VF, 11 patients had chest pain or tightness, and another patient had a history of syncope. Only 1 patient had a family history of premature SD. The coronary angiograms were normal in all the patients. VF was induced in 5 patients (36%). Wall motion abnormalities of the right ventricle were detected in 4 patients (29%) and endomyocardial biopsy revealed features of cardiomyopathy in 7 patients (50%). In total, 9 (64%) of 14 patients exhibited wall motion abnormalities and/or pathologic findings. CONCLUSIONS: Underlying cardiomyopathy was present in more than half of the present patients with ST-segment elevation in the right precordial leads.
Authors:
Hyungseop Kim; Yongkeun Cho; Yonghwi Park; Hyunsang Lee; Hyunjae Kang; Deuk-Young Nah; Taein Park; Dong Heon Yang; Hun Sik Park
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  70     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-25     Completed Date:  2006-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  719-25     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Department of Internal Medicine, Kyungpook National University, Taegu, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biopsy
Cardiomyopathies / drug therapy,  pathology*,  physiopathology*,  ultrasonography
Coronary Angiography
Death, Sudden / pathology
Echocardiography
Electrocardiography*
Heart / physiopathology
Heart Ventricles / pathology,  physiopathology,  ultrasonography
Humans
Male
Middle Aged
Sodium Channel Blockers / administration & dosage
Ventricular Fibrillation / drug therapy,  pathology,  physiopathology,  ultrasonography
Chemical
Reg. No./Substance:
0/Sodium Channel Blockers

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