Document Detail

Underexpression of cyclin-dependent kinase (CDK) inhibitors in cervical carcinoma.
MedLine Citation:
PMID:  9784316     Owner:  NLM     Status:  MEDLINE    
Recent studies have revealed a new family of tumor suppressor genes that directly implicate aberrant cell cycle regulation in tumorigenesis. The general function of these gene products is that they prevent cell cycle progression by directly interfering with cyclin/cyclin-dependent kinase (CDK) activation. The importance of these genes is that they are potent inhibitors of CDK. Among these cell cycle inhibitors, p21(WAF1/CIP1) and p16 have been thoroughly studied. However, the role of p21(WAF1/CIP1) and p16 in the tumorigenesis of the uterine cervix has been poorly defined. We used immunohistochemical techniques to study the expression of these cell cycle inhibitors in formalin-fixed, paraffin-embedded cervical tissue to explore the relationship between cyclin/CDK inhibitors and cervical carcinoma. Cervical tissues were analyzed from 46 patients with cervical carcinoma, 30 cases with cervical intraepithelial neoplasia (CIN) and 22 control cases who underwent hysterectomy due to benign gynecologic disease at Yonsei University College of Medicine. All CDK inhibitors were strongly expressed in the reverse cell hyperplasia and koilocytes, whereas they revealed significantly decreased expression in neoplastic tissues (P < 0.05). P16 revealed higher expressions in cases associated with human papillomavirus (HPV) (t test, P < 0.05) than in cases lacking any type of HPV. Our results were consistent with the concept that underexpression of CDK inhibitors may play an important role in neoplastic transformation in cervical carcinoma.
Y T Kim; N H Cho; S W Park; J W Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecologic oncology     Volume:  71     ISSN:  0090-8258     ISO Abbreviation:  Gynecol. Oncol.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-11-19     Completed Date:  1998-11-19     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0365304     Medline TA:  Gynecol Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  38-45     Citation Subset:  IM    
Copyright Information:
Copyright 1998 Academic Press.
Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, 120-752, Korea.
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MeSH Terms
Carcinoma / metabolism*,  pathology
Carcinoma in Situ / metabolism,  pathology
Cyclin-Dependent Kinase Inhibitor p16 / metabolism
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinases / antagonists & inhibitors*
Cyclins / metabolism
DNA, Viral / metabolism
Enzyme Inhibitors / metabolism
Gene Expression
Middle Aged
Papillomaviridae / genetics
Tumor Markers, Biological / metabolism
Uterine Cervical Neoplasms / metabolism*,  pathology
Reg. No./Substance:
0/CDKN1A protein, human; 0/Cyclin-Dependent Kinase Inhibitor p16; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/Cyclins; 0/DNA, Viral; 0/Enzyme Inhibitors; 0/Tumor Markers, Biological; EC Kinases

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