Document Detail

Underestimation of albumin content by bromocresol green, induced by drug displacers and uremia.
MedLine Citation:
PMID:  3988397     Owner:  NLM     Status:  MEDLINE    
Phenylbutazone and clofibric acid, two drugs strongly bound to human albumin, produce low readings of albumin content in serum when the bromocresol green immediate reaction is used. This abnormality is observed at drug concentrations within the range obtained during therapeutic use, and tends to be more marked in diluted samples of serum. Abnormally low values of albumin content are also obtained when the bromocresol green method is used in uremic sera, and the disparity seems related to the degree of carbamylation of these samples. The reported interferences are great enough in some cases as to suggest that the use of the immediate reaction between bromocresol green and serum should not be considered a valid measure of albumin content when these factors cannot be totally excluded.
R Calvo; R Carlos; S Erill
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology, therapy, and toxicology     Volume:  23     ISSN:  0174-4879     ISO Abbreviation:  Int J Clin Pharmacol Ther Toxicol     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-05-28     Completed Date:  1985-05-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003415     Medline TA:  Int J Clin Pharmacol Ther Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  76-8     Citation Subset:  IM    
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MeSH Terms
Bromcresol Green / diagnostic use*,  metabolism
Clofibrate / analogs & derivatives*
Clofibric Acid / pharmacology*
Cresols / diagnostic use*
Electrophoresis, Cellulose Acetate
Phenylbutazone / pharmacology*
Protein Binding
Serum Albumin / metabolism*
Uremia / metabolism*
Reg. No./Substance:
0/Cresols; 0/Serum Albumin; 50-33-9/Phenylbutazone; 637-07-0/Clofibrate; 76-60-8/Bromcresol Green; 882-09-7/Clofibric Acid

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