| Undercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in symptomatic aortic stenosis. | |
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MedLine Citation:
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PMID: 20804515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Matrix Gla protein (MGP) is a calcification inhibitor and alterations in circulating MGP have been observed in different populations characterized by vascular calcification. We hypothesized that patients with calcific valvular aortic stenosis (AS) would have dysregulated circulating MGP levels. DESIGN AND SUBJECTS: We examined plasma levels of nonphosphorylated carboxylated and undercarboxylated MGP (dp-cMGP and dp-ucMGP, respectively) in 147 patients with symptomatic severe AS and in matched healthy controls. MAIN OUTCOME MEASURES: We further investigated the relationship between MGP levels and aortic pressure gradients and valve area by echocardiography and measures of heart failure. Finally, we assessed the prognostic value of elevated plasma dp-ucMGP level in relation to all-cause mortality in patients with AS. RESULTS: We found markedly enhanced plasma levels of dp-cMGP and in particular of dp-ucMGP in patients with symptomatic AS. Although only weak correlations were found with the degree of AS, circulating dp-ucMGP was associated with cardiac function and long-term mortality in multivariate analysis. CONCLUSIONS: A dysregulated MGP system may have a role in the development of left ventricular dysfunction in patients with symptomatic AS. |
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Authors:
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T Ueland; L Gullestad; C P Dahl; P Aukrust; S Aakhus; O G Solberg; C Vermeer; L J Schurgers |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of internal medicine Volume: 268 ISSN: 1365-2796 ISO Abbreviation: J. Intern. Med. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-22 Completed Date: 2010-11-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904841 Medline TA: J Intern Med Country: England |
Other Details:
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Languages: eng Pagination: 483-92 Citation Subset: IM |
Copyright Information:
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© 2010 The Association for the Publication of the Journal of Internal Medicine. |
Affiliation:
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Research Institute for Internal Medicine, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway. thor.ueland@medisin.uio.no |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Anticoagulants / therapeutic use Aorta / pathology, ultrasonography Aortic Valve / pathology, ultrasonography Aortic Valve Stenosis / blood*, drug therapy, mortality* Biological Markers / blood Blood Pressure / physiology Calcinosis / blood, mortality Calcium-Binding Proteins / blood, metabolism* Cause of Death Echocardiography Extracellular Matrix Proteins / blood* Female Heart Failure / blood* Humans Male Middle Aged Prognosis Warfarin / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Biological Markers; 0/Calcium-Binding Proteins; 0/Extracellular Matrix Proteins; 0/matrix Gla protein; 81-81-2/Warfarin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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