Document Detail

Undercarboxylated osteocalcin is a biomarker of carotid calcification in patients with essential hypertension.
MedLine Citation:
PMID:  20197689     Owner:  NLM     Status:  MEDLINE    
The development of vascular calcification is an active, highly regulated process with similarities to bone formation. Osteocalcin (OC), a vitamin K-dependent protein expressed by osteoblasts, contains 3 gamma-carboxyglutamic acid residues derived from the vitamin K-dependent posttranslational modification of glutamic acid residues. Circulating undercarboxylated OC (ucOC) is increased in vitamin K deficiency and serum ucOC is reported to be a clinical marker of vitamin K status. Vitamin K deficiency is associated with vascular calcification as well as osteoporosis. We evaluated the relationship between ucOC and carotid artery calcification in 92 patients with essential hypertension. Ultrasound of the common carotid artery was performed to identify vascular calcification and subjects were divided into 2 groups: a calcification (+) group and a calcification (-) group. Serum creatinine and ucOC levels were higher in the calcification (+) group than in the calcification (-) group and serum ucOC correlated with serum creatinine. To identify the independent determinant factor for carotid artery calcification, we applied both ucOC and estimated glomerular filtration rate as independent factors in logistic regression analysis. Serum ucOC was an independent determinant of carotid calcification, suggesting that circulating ucOC may be an important biomarker of carotid artery calcification.
Takafumi Okura; Mie Kurata; Daijiro Enomoto; Masanori Jotoku; Tomoaki Nagao; Veena Rasika Desilva; Jun Irita; Ken-Ichi Miyoshi; Jitsuo Higaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-02
Journal Detail:
Title:  Kidney & blood pressure research     Volume:  33     ISSN:  1423-0143     ISO Abbreviation:  Kidney Blood Press. Res.     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-26     Completed Date:  2010-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610505     Medline TA:  Kidney Blood Press Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  66-71     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon City, Japan.
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MeSH Terms
Biological Markers / blood*
Calcinosis / metabolism*,  ultrasonography
Carotid Stenosis / metabolism*,  ultrasonography
Creatinine / blood
Glomerular Filtration Rate
Hypertension / metabolism*,  ultrasonography
Logistic Models
Middle Aged
Osteocalcin / blood*
Reg. No./Substance:
0/Biological Markers; 104982-03-8/Osteocalcin; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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