| Under-expression of CD24 in pre-eclamptic placental tissues determined by quantitative real-time RT-PCR. | |
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MedLine Citation:
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PMID: 18417991 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Pre-eclampsia is a pregnancy-related disorder present in about 5-7% of all pregnancies. CD24 expression was recently reported in different diseases, while it has not yet been determined in pre-eclamptic placental tissues. METHODS: We collected placental tissues from pre-eclamptic (n = 16) and healthy pregnancies (n = 16). We used the quantitative real-time PCR method with a primer-probe system for determination of CD24 gene expression. RESULTS: We measured CD24 concentrations of 18.94 +/- 26.86 ng/microl in the pre-eclamptic and 53.85 +/- 92.05 ng/microl in the healthy placental tissues (p = 0.03). CONCLUSIONS: The quantitative real-time PCR method is suitable to determine CD24 expression in placental tissues. We suppose the low expression of CD24 may cause the enhanced immune reaction and could play a role in the abnormal development of placenta in pre-eclampsia. |
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Authors:
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Bálint Nagy; Eniko Berkes; Barbara Rigó; Zoltán Bán; Zoltán Papp; Petronella Hupuczi |
Publication Detail:
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Type: Journal Article Date: 2008-04-14 |
Journal Detail:
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Title: Fetal diagnosis and therapy Volume: 23 ISSN: 1421-9964 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-04-17 Completed Date: 2008-06-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: Switzerland |
Other Details:
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Languages: eng Pagination: 263-6 Citation Subset: IM |
Copyright Information:
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(c) 2008 S. Karger AG, Basel. |
Affiliation:
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1st Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary. nabal@noi1.sote.hu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD24 / genetics* Case-Control Studies Female Gene Expression HELLP Syndrome / genetics, immunology Humans Placenta / immunology* Pre-Eclampsia / genetics*, immunology* Pregnancy RNA / genetics, metabolism Reverse Transcriptase Polymerase Chain Reaction |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD24; 0/CD24 protein, human; 63231-63-0/RNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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