Document Detail


Under-expression of CD24 in pre-eclamptic placental tissues determined by quantitative real-time RT-PCR.
MedLine Citation:
PMID:  18417991     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Pre-eclampsia is a pregnancy-related disorder present in about 5-7% of all pregnancies. CD24 expression was recently reported in different diseases, while it has not yet been determined in pre-eclamptic placental tissues. METHODS: We collected placental tissues from pre-eclamptic (n = 16) and healthy pregnancies (n = 16). We used the quantitative real-time PCR method with a primer-probe system for determination of CD24 gene expression. RESULTS: We measured CD24 concentrations of 18.94 +/- 26.86 ng/microl in the pre-eclamptic and 53.85 +/- 92.05 ng/microl in the healthy placental tissues (p = 0.03). CONCLUSIONS: The quantitative real-time PCR method is suitable to determine CD24 expression in placental tissues. We suppose the low expression of CD24 may cause the enhanced immune reaction and could play a role in the abnormal development of placenta in pre-eclampsia.
Authors:
Bálint Nagy; Eniko Berkes; Barbara Rigó; Zoltán Bán; Zoltán Papp; Petronella Hupuczi
Publication Detail:
Type:  Journal Article     Date:  2008-04-14
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  23     ISSN:  1421-9964     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-17     Completed Date:  2008-06-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  263-6     Citation Subset:  IM    
Copyright Information:
(c) 2008 S. Karger AG, Basel.
Affiliation:
1st Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary. nabal@noi1.sote.hu
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD24 / genetics*
Case-Control Studies
Female
Gene Expression
HELLP Syndrome / genetics,  immunology
Humans
Placenta / immunology*
Pre-Eclampsia / genetics*,  immunology*
Pregnancy
RNA / genetics,  metabolism
Reverse Transcriptase Polymerase Chain Reaction
Chemical
Reg. No./Substance:
0/Antigens, CD24; 0/CD24 protein, human; 63231-63-0/RNA

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